2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. AT-0174

AT-0174 是一种具有口服活性的 IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) 双重抑制剂，IC50 值分别为0.17 和 0.25 μM。AT-0174 具有抗肿瘤活性。

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AT-0174 Chemical Structure

AT-0174 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

AT-0174 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AT-0174 is an orally active dual inhibitor of IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) with IC50 values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity[1][2].

IC50 & Target

IDO1

0.17 μM (IC50)

体外研究
(In Vitro)

AT-0174 (170 mg/kg/day, 口服, 连续 15 天) 可抑制非小细胞肺癌异体移植小鼠的肿瘤生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AT-0174 相关抗体:
分子量

189.57

Formula

C6H5ClFN3O
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AT-0174 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AT-0174AT0174AT 0174Indoleamine 2,3-Dioxygenase (IDO)IODInhibitorAntitumorinhibitorinhibit

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产品名称：
AT-0174
目录号：
HY-161348
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