2. Anti-infection
  3. SARS-CoV
  4. BPR3P0128

BPR3P0128 是一种具有口服活性的非核苷类 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂，可以抑制各种 SARS-CoV-2 变异体的活性，对 SARS-CoV-2 和 HCoV-229E 的 EC50 分别为 0.62 和 0.14 µM，BPR3P0128 在亚微摩尔范围内具有有效的抗泛冠状病毒活性。BPR3P0128 与 Remdesivir (HY-104077) 联合使用时表现出协同的抗病毒活性。

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BPR3P0128 Chemical Structure

BPR3P0128 Chemical Structure

CAS No. : 1345406-09-8

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BPR3P0128 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC50 for SARS-CoV-2 and HCoV-229E are 0.62 µM and 0.14 µM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077)[1].

体外研究
(In Vitro)

BPR3P0128 (10 μM, 24 小时) 能有效抑制人肺癌细胞株 Calu-3 中 SARS-CoV-2 的复制以及降低由病毒感染引起的细胞因子的表达[1]。
BPR3P0128 (1 μM, 10 μM) 对冠状病毒具有全面的活性，可有效抑制不同的 SARS-CoV-2 (包括 α、 β、 γ、 δ 以及组粒菌株) 变体[1]。
BPR3P0128 (1 μM, 2 μM; 24 小时) 与 Remdesivir (HY-104077) (4 μM, 8 μM) 联合使用时表现出协同的抗病毒活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BPR3P0128 相关抗体:

RT-PCR[1]

Cell Line: Vero E6 cells containing SARS-CoV-2 virus
Concentration: 10 μM
Incubation Time: 0-24h
Result: Significantly decreased the mRNA expression levels of CXCL10, IL-6, TNF-α and INF-β.

Western Blot Analysis[1]

Cell Line: Vero E6 cells containing SARS-CoV-2 virus
Concentration: BPR3P0128: 1 μM, 2 μM; Remdesivir: 4 μM, 8 μM
Incubation Time: 24h
Result: And Remdesivir synergistically inhibited NP expression more significantly.

Western Blot Analysis[1]

Cell Line: HEK293T cell-based RdRp reporter model
Concentration: BPR3P0128: 0.1 μM, 1 μM, 10 μM; Remdesivir: 1 μM, 10 μM, 100 μM
Incubation Time: 24h
Result: Inhibited the activity of SARS-CoV-2 RdRp, but did not decrease the expression level of nsp12.
体内研究
(In Vivo)


药代动力学分析[1]

Route Dose (mg/kg) Cl (mL•min/kg) t1/2 (h) F (%)
i.v. 0.01 1.3 / /
p.o. 0.01 / 8.1 78.7%

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

436.30

Formula

C22H18BrN3O2
CAS 号
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BPR3P0128 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPR3P01281345406-09-8SARS-CoVSARS coronavirusHydroxychloroquineSARS-CoV-2HCoV-229EAntiviralRemdesivirSARS-CoV-2 variantsInhibitorinhibitorinhibit

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目录号：
HY-161356
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