2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. CBR Agonist-1

CBR Agonist-1 (27a-cis) 是大麻素受体 (CBR) 激动剂，作用于 CB1R 和 CB2R 的 Ki 值分别是 0.18 μM 和 1.22 μM。CBR Agonist-1 (27a-cis) 可用于内源性大麻素系统相关疾病的研究。

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CBR Agonist-1 Chemical Structure

CBR Agonist-1 Chemical Structure

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CBR Agonist-1 相关抗体

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CBR Agonist-1 (27a-cis) is a cannabinoid receptor (CBR) agonist with the Ki values of 0.18 μM for CB1R and 1.22 μM for CB2R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases[1].
IC50 & Target[1]

rCB1-R

0.18 μM (Ki)

hCB2-R

1.22 μM (Ki)

体外研究
(In Vitro)

CBR Agonist-1 (27a-cis) (24 h) can activate GRABeCB2.0 (fluorescent CB1R sensor) in a concentration-dependent manner with the EC50 value of 2.1 μM in HEK293T cell lines[1].
CBR Agonist-1 (27a-cis) (0-10 mM) acts on hCB1R calcium mobilization with the IC50 value of 3.10 μM in overexpressed hCB1R CHO-K1cells[1].
CBR Agonist-1 (27a-cis) (10-1000 nM, 15 min) induces increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in a dose-dependent manner in expressed Gαq16 and hCB1 CHO cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CBR Agonist-1 相关抗体:
分子量

442.53

Formula

C27H27FN4O
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CBR Agonist-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBR Agonist-1CBR Agonist1CBR Agonist 1Cannabinoid Receptorcannabinoid receptorCBRCB1RCB2RInhibitorinhibitorinhibit

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目录号：
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