2. Cell Cycle/DNA Damage Stem Cell/Wnt PI3K/Akt/mTOR
  3. CDK GSK-3
  4. CDK7-IN-20

CDK7-IN-20 是一种有效的、选择性的、不可逆的 CDK7 (CDK) 抑制剂，IC50 值为 4 nM。CDK7-IN-20 对 CDK7 的选择性超过 CDK1、CDK2、CDK3、CDK5、CDK6、CDK9 和 CDK12 的 206 倍以上。CDK7-IN-20 具有用于常染色体显性多囊肾病 (ADPKD) 研究的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7-IN-20 Chemical Structure

CDK7-IN-20 Chemical Structure

CAS No. : 3034210-97-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CDK7-IN-20 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 GSK-3 亚型特异性产品:

查看所有亚型
GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK7-IN-20 is a potent, selective and irreversible CDK7 (CDK) inhibitor with an IC50 value of 4 nM. CDK7-IN-20 displays >206-fold selectivity for CDK7 over CDK1, CDK2, CDK3, CDK5, CDK6, CDK9 and CDK12 . CDK7-IN-20 has the potential for autosomal dominant polycystic kidney disease (ADPKD) research[1].

IC50 & Target[1]

CDK7

4 nM (IC50)

CDK1

3375 nM (IC50)

CDK2

823 nM (IC50)

CDK3

1837 nM (IC50)

CDK5

>10,000 nM (IC50)

CDK6

950 nM (IC50)

CDK9

526 nM (IC50)

CDK12

>10,000 nM (IC50)

GSK3β

148 nM (IC50)

体外研究
(In Vitro)

In Madin-Darby canine kidney (MDCK) cells, CDK7-IN-20 (Compound B2; 1-3 μM; from day 4 to day 12) shows high potency to inhibit cyst growth and exhibited lower cytotoxicity than THZ1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-20 相关抗体:
体内研究
(In Vivo)

CDK7-IN-20 (Compound B2; 5 mg/kg; s.c; once daily; for 6 days) significantly reduces the kidney size and cyst formation of the ADPKD mice. The protein expression of AMPD3 could be significantly down-regulated by CDK7-IN-20 in the cyst-lining epithelial cells of the ADPKD mouse kidney[1].
ADME Profiles of CDK7-IN-20 (Compound B2)a[1].

CDK7-IN-20 (Compound B2)
parameters i.v. 5 mg/kg s.c. 5 mg/kg
AUClast (h·ng/mL) 26,937 17,280
AUCIFN_obs (h·ng/mL) 31,698 17,411
t1/2 (h) 17.8 3.4
Tmax (h) 0.5
Cmax (h) 3806
Cl_obs (mL/min/kg) 2.80
Vss_obs (mL/kg) 1275
MRTIFN_obs (h) 10.2 4.8
F (%) 64.2
plasma protein binding (bound%)b >99
permeability of Caco-2 A to B Papp (10–6 cm/s)/B to A Papp (10–6 cm/s)/efflux ratioc <0.133/6.370/>48.0
aThree ICR mice were used for each group. The data are expressed as mean values.
bPlasma from mouse. PPB was tested at 1 and 10 μM substrate concentrations.
bCaco-2 membrane permeability at 10 μM substrate concentrations. The value of 0.133 was determined by quantitative limit (1.0 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neonatal Pkd1flox/flox:Ksp-Cre mice[1]
Dosage: 5 mg/kg
Administration: Subcutaneous administration; once daily; for 6 days
Result: Significantly reduced the kidney size and cyst formation of the ADPKD mice.
分子量

518.57

Formula

C30H26N6O3
CAS 号
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK7-IN-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-203034210-97-1CDKGSK-3Cyclin dependent kinaseGlycogen synthase kinase-3Glycogen synthase kinase 3CDK7 inhibitorirreversibleautosomal dominant polycystic kidney diseaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CDK7-IN-20
目录号：
HY-151878
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z