2. Immunology/Inflammation
  3. Interleukin Related
  4. Cendakimab

Cendakimab  (Synonyms: 申达奇单抗; RPC 4046; ABT 308; CC-93538)

目录号: HY-P99496 纯度: 99.96%
COA

摩尔计算器

Cendakimab (RPC4046; ABT 308; CC-93538) 是一种选择性的、人源化的 IL-13 重组单克隆抗体。Cendakimab 对人野生型和变异体 IL-13 具有高亲和力和效力，并阻断 IL-13 与 IL-13Rα1 和 IL-13Rα2 的结合，通过 ELISA 测定的 IC50 分别为 352 pM 和 631 pM。Cendakimab 识别野生型人 IL-13 和常见的多态变体 R110Q，结合力分别为 52 pM 和 50 pM。Cendakimab 具有潜力用于 IL-13 相关过敏/炎症性疾病，例如哮喘和嗜酸性粒细胞性食管炎。

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Cendakimab Chemical Structure

Cendakimab Chemical Structure

CAS No. : 2151032-62-9

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规格 价格 是否有货 数量
1 mg ￥2500
In-stock
5 mg ￥7000
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Cendakimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis)[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target[1]

IL-13

 

体外研究
(In Vitro)

Cendakimab (RPC4046; ABT 308; CC-93538) 完全中和肺上皮 A-549 细胞中 IL-13 诱导的胸腺和活化调节趋化因子，效力范围为 80 至 513 pM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cendakimab 相关抗体:
Clinical Trial
CAS 号
非同位 CAS

性状

液体

颜色

Colorless to light yellow

中文名称

申达奇单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cendakimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cendakimab2151032-62-9RPC 4046 ABT 308 CC-93538申达奇单抗RPC4046RPC-4046ABT308ABT 308ABT-308CC93538CC 93538CC-93538Interleukin RelatedILAntibodyIL-13IL-13Rα1IL-13Rα2R110Qallergicinflammatory diseasesasthmaeosinophilic esophagitisInhibitorinhibitorinhibit

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