2. Apoptosis
  3. TNF Receptor
  4. Conatumumab

Conatumumab  (Synonyms: AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody)

目录号: HY-P99260 纯度: 98.90%
COA

摩尔计算器

Conatumumab (AMG 655) 是一种针对人死亡受体 5 (DR5，TRAILR2) 的单克隆激动剂抗体 (Kd: 长型 DR5 为 1 nM, 短型 DR5 为 0.8 nM)。Conatumumab 通过激活 caspase 诱导细胞凋亡 (apoptosis)。Conatumumab 可用于癌症研究。

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Conatumumab Chemical Structure

Conatumumab Chemical Structure

CAS No. : 896731-82-1

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1 mg ￥4600
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Conatumumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. [1][2][3].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Human
IC50 & Target

IC50: DR5 (<1 nM)[2]
体外研究
(In Vitro)

Conatumumab (0-10 μg/mL，4 小时) 激活 Colo205、H-2122 和 MiaPaCa2 细胞中的 caspase-3/7[2]。
Conatumumab (0-10 μg/mL，24 小时) 降低敏感肿瘤细胞系 (Colo205、H-2122 和 MiaPaCa2 细胞) 的细胞活力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Conatumumab 相关抗体:

Cell Viability Assay[2]

Cell Line: Colo205, H-2122, and MiaPaCa2 cells
Concentration: 0-10 μg/mL
Incubation Time: 24 h
Result: Dose-dependently inhibited cell viability.
体内研究
(In Vivo)

Conatumumab (0-100 μg，腹腔注射，每周两次) 抑制 Colo205、H2122 或 MiaPaCa2/T2 异种移植肿瘤的小鼠的肿瘤生长[2]。
Conatumumab (2.5 μg，i.p.，每周 3 次) 增强化疗药物 (CPT11，HY- 16562) (80 mg/kg) 在 Colo 205 移植瘤中的抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors[2]
Dosage: 0, 0.1, 0.3, 1, 3, 10, 30, 100 μg
Administration: Intraperitoneal injection (i.p.), twice weekly.
Result: Dose-dependently inhibited tumor growth.
Induced caspase-3 activation in tumors (determined by IHC).
Clinical Trial
分子量

145.65 (kDa)

CAS 号
非同位 CAS

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.90%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Conatumumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conatumumab896731-82-1AMG 655 TRAIL-R2 mAb Human Anti-TNFRSF10B Recombinant AntibodyAMG655AMG-655TNF ReceptorTumor Necrosis Factor ReceptorTNFRTumorColo 205H-2122MiaPaCa2DR5caspaseanti-cancerInhibitorinhibitorinhibit

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