2. GPCR/G Protein
  3. GnRH Receptor
  4. Fsh receptor-binding inhibitor fragment(bi-10)

Fsh receptor-binding inhibitor fragment(bi-10) 

目录号: HY-P4190 纯度: 99.61%
COA 产品使用指南

摩尔计算器

FSH receptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSH receptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合，并在受体水平上改变 FSH 的作用。FSH receptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSH receptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ 的过度表达来抑制卵巢癌发生。

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Custom Peptide Synthesis

Fsh receptor-binding inhibitor fragment(bi-10) Chemical Structure

Fsh receptor-binding inhibitor fragment(bi-10) Chemical Structure

CAS No. : 163973-98-6

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规格 价格 是否有货 数量
1 mg ￥550
In-stock
5 mg ￥1300
In-stock
10 mg ￥2100
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Fsh receptor-binding inhibitor fragment(bi-10) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries[1].

体内研究
(In Vivo)

FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; 肌肉注射; 每天1次; 连续5天) 在大剂量 (30 mg/kg-40 mg/kg) 可抑制卵巢和卵泡发育，降低卵巢中 ERβ 和 FSHR mRNA 和蛋白质的表达水平，抑制 E2 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Prepuberty Kunming female mice of 21-days old and body weight of 22.3±1.52g[1]
Dosage: 10, 20, 30, 40 mg/kg
Administration: Intramuscularly injection; once a day for five consecutive days
Result: Could attenuate FSH promoting effect on the follicular development, resulting in the poor maturation of ovarian follicles.
High dose (40mg/kg) treatment blocked the follicle development of mice.
High dose of FRBI (40mg/kg) treatment blocked the follicle development of mice.
分子量

1058.06

Formula

C42H67N13O19
CAS 号
Unlabeled Cas

性状

固体

颜色

White to off-white

Sequence

Thr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2
Sequence Shortening

TENLEPNGEG-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (94.51 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9451 mL 4.7256 mL 9.4513 mL
5 mM 0.1890 mL 0.9451 mL 1.8903 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Fsh receptor-binding inhibitor fragment(bi-10) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9451 mL 4.7256 mL 9.4513 mL 23.6281 mL
5 mM 0.1890 mL 0.9451 mL 1.8903 mL 4.7256 mL
10 mM 0.0945 mL 0.4726 mL 0.9451 mL 2.3628 mL
15 mM 0.0630 mL 0.3150 mL 0.6301 mL 1.5752 mL
20 mM 0.0473 mL 0.2363 mL 0.4726 mL 1.1814 mL
25 mM 0.0378 mL 0.1890 mL 0.3781 mL 0.9451 mL
30 mM 0.0315 mL 0.1575 mL 0.3150 mL 0.7876 mL
40 mM 0.0236 mL 0.1181 mL 0.2363 mL 0.5907 mL
50 mM 0.0189 mL 0.0945 mL 0.1890 mL 0.4726 mL
60 mM 0.0158 mL 0.0788 mL 0.1575 mL 0.3938 mL
80 mM 0.0118 mL 0.0591 mL 0.1181 mL 0.2954 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fsh receptor-binding inhibitor fragment(bi-10)163973-98-6GnRH ReceptorGonadotropin releasing hormone receptorGNRHRFSHFSHRovulationfollicular atresiacarcinogenesisovarian cancerERβInhibitorinhibitorinhibit

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