1. Gene
  2. EGR3 - early growth response 3 Gene

EGR3 - early growth response 3 Gene

中文名称:早期生长反应 3

种属: Homo sapiens

同用名: EGR-3; PILOT

基因 ID: 1960 | 基因类型: protein coding

关于 EGR3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,687,659-22,693,480 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 4 paralogues. Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues.

功能概要

该基因编码属于 C2H2 型锌指蛋白 EGR 家族的转录调节因子。它是由促有丝分裂刺激诱导的即刻早期生长反应基因。该基因编码的蛋白质参与了控制生物节律的基因的转录调控。它还可能在多种过程中发挥作用,包括肌肉发育、淋巴细胞发育、内皮细胞生长和迁移以及神经元发育。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2010 年 12 月]

This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

EGR3 基因产物(3)

mRNA Protein Name
NM_001199880.2 NP_001186809.1 early growth response protein 3 isoform 2
NM_001199881.2 NP_001186810.1 early growth response protein 3 isoform 3
NM_004430.3 NP_004421.2 early growth response protein 3 isoform 1

EGR3 蛋白结构

DUF3446

DUF3446: Domain of unknown function (DUF3446) (87 - 156)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (292 - 315)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (319 - 343)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
蛋白主名 其他名称

early growth response protein 3

zinc finger protein pilot

关联疾病

疾病名称 别名
Patella, Chondromalacia Of

Chondromalacia Patellae

Chondromalacia Of Patella

Softening Of Articular Cartilage Of Patella

Patellofemoral Pain Syndrome

Patellofemoral Chondromalacia

Schizophrenia 19

SCZD19

Schizophrenia 19 With Or Without An Affective Disorder

Schizophrenia 19, Susceptibility To

{Schizophrenia 19, Susceptibility To}

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4

Charcot-Marie-Tooth Disease Type 4e

Hereditary Motor And Sensory Neuropathy

Cmt4e

CHN1

Hypomyelinating Neuropathy, Congenital, 1

Charcot-Marie-Tooth Neuropathy Type 4e

Neuropathy, Congenital Hypomyelinating, 1

Ar-Cmt1

Autosomal Recessive Demyelinating Charcot-Marie-Tooth

Cmt4

Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

Hypomyelination, Severe Congenital

Charcot-Marie-Tooth Disease, Type 4e

Charcot-Marie-Tooth Neuropathy, Type 4e

Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

Autosomal Recessive Congenital Hypomyelinating Neuropathy

Congenital Amyelinating Neuropathy

Congenital Hypomyelinating Neuropathy Autosomal Recessive

Neuropathy, Congenital Hypomyelinating Or Amyelinating

Severe Congenital Hypomyelination

Hereditary Sensory Motor Neuropathy

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

Neuropathy, Hypomyelinating, Congenital, Type 1

Neuropathy, Motor And Sensory, Hereditary

Congenital Hypomyelinating Neuropathy

Hereditary Motor And Sensory Neuropathies

Hereditary Sensorimotor Neuropathy

Hmsn - [Hereditary Motor And Sensory Neuropathy]

Hsmn - [Hereditary Sensory And Motor Neuropathy]

Hereditary Motor And Sensory Neuropathy, Types I-Iv

Hypertrophic Neuropathy Of Dejerine-Sottas

Dejerine-Sottas Disease

Dejerine-Sottas Syndrome

Charcot-Marie-Tooth Disease Type 3

DSS

Hereditary Motor And Sensory Neuropathy Type Iii

Hmsn3

Dejerine-Sottas Neuropathy

Hmsn Iii

Charcot-Marie-Tooth Disease, Type 3

Cmt3

Dsn

Hmsn 3

Hereditary Motor And Sensory Neuropathy Type 3

Hereditary Motor And Sensory Neuropathy 3

Hypertrophic Neuropathy Of Infancy

Charcot-Marie-Tooth Disease Demyelinating Type 4f

Charcot-Marie-Tooth Disease Type 4f

Charcot-Marie-Tooth Neuropathy Type 4f

Cmt4f

Hereditary Motor And Sensory Neuropathy Iii

Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus EGR3 VGNC VGNC:28368
Felis catus EGR3 VGNC VGNC:61761
Canis familiaris EGR3 VGNC VGNC:40242
Macaca mulatta EGR3 VGNC VGNC:104449
Rattus norvegicus EGR3 RGD RGD:2545
Mus musculus EGR3 MGD MGI:1306780