2. MAPK/ERK Pathway
  3. JNK
  4. JNK-IN-8

JNK-IN-8  (Synonyms: JNK Inhibitor XVI)

目录号: HY-13319G
产品使用指南

摩尔计算器

JNK-IN-8 (JNK Inhibitor XVI) (GMP) 是 GMP 级别的 JNK-IN-8 (HY-13319)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。JNK-IN-8 是一种有效的 JNK 抑制剂，抑制 JNK1，JNK2 和 JNK3，IC50 分别为 4.7 nM，18.7 nM 和 1 nM。

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JNK-IN-8 Chemical Structure

JNK-IN-8 Chemical Structure

CAS No. : 1410880-22-6

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JNK-IN-8 的其他形式现货产品:

Customer Review

Other Forms of JNK-IN-8:

JNK-IN-8 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 34 篇科研文献

WB

    JNK-IN-8 purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 May 4;37(1):99.  [Abstract]

    A co-inhibitor of JNK and integrin β obviously decreases phosphorylation levels of JNK and c-JUN and expression of LOXL2 as compared with JNK inhibitor alone or integrin β1 alone.

    JNK-IN-8 purchased from MCE. Usage Cited in: J Biol Chem. 2014 Oct 17;289(42):28753-64.  [Abstract]

    Effect of the JNK inhibitor (JNK IN 8) on the induction of MKP-1 and MKP-2. RAW264.7 cells are first pretreated with vehicle (DMSO), 3 μM JNK IN 8, 10 μM of U0126, or a combination of both JNK IN 8 and U0126, for 30 min, and then stimulated with LPS for 60 min. Representative images are shown in the panels.

    查看 JNK 亚型特异性产品:

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    JNK1 JNK2 JNK3 JNK

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].

    IC50 & Target

    IC50: 4.7/18.7/1 nM (JNK1/2/3)[1]
    体外研究
    (In Vitro)

    JNK-IN-8 (GMP) (10 μM) 减少 WNT3A 介导的神经元分化[1]。
    JNK-IN-8 (GMP) (2 μM，7 天) 通过下调 C-JUN 磷酸化来增强人类造血干细胞 (HSC) 的自我更新[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    JNK-IN-8 相关抗体:
    分子量

    507.59

    Formula

    C29H29N7O2
    CAS 号
    非同位 CAS

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    JNK-IN-8 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JNK-IN-8 (GMP)1410880-22-6JNK Inhibitor XVI (GMP)JNKc-Jun N-terminal kinaseGMPcell therapydifferentiatestem cellHSCsInhibitorinhibitorinhibit

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