2. NF-κB Autophagy
  3. IKK ULK Autophagy
  4. MRT67307 dihydrochloride

MRT67307 dihydrochloride 是 IKKε 和 TBK-1 的双抑制剂，IC50 分别为 160 和 19 nM。MRT67307 dihydrochloride 也可抑制 ULK1 和 ULK2，IC50 分别为 45 和 38 nM。MRT67307 dihydrochloride 还抑制细胞自噬 (autophagy)。

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MRT67307 dihydrochloride Chemical Structure

MRT67307 dihydrochloride Chemical Structure

CAS No. : 1781882-89-0

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MRT67307 dihydrochloride 的其他形式现货产品:

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MRT67307 dihydrochloride 相关抗体

Top Publications Citing Use of Products

    MRT67307 dihydrochloride purchased from MCE. Usage Cited in: Nat Med. 2018 Aug;24(8):1143-1150.  [Abstract]

    Immunoblot of pSTAT1, STAT1 and β-actin levels in H69AR cells±200 ng/mL IFNg 10 min pulse followed by 24 h chase in media with DMSO, Ruxolitinib (100 nM) or MRT67307 (1 µM).

    MRT67307 dihydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2015 Jan 21;6:6074.  [Abstract]

    MRT67307 efficiently inhibits the AKT degradation. IB analysis using WT CD4+ T cells, pretreated for 1 h with a TBK1 inhibitor, MRT67307, of solvent control DMSO and subsequently stimulated for the indicated times with anti-CD3 plus anti-CD28 in the presence of a protein synthesis inhibitor, Cycloheximide.

    查看 IKK 亚型特异性产品:

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    IKK-α IKK-β IKK IKKε TBK1

    查看 ULK 亚型特异性产品:

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    ULK1 ULK2

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].

    分子量

    537.52

    Formula

    C26H38Cl2N6O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    MRT67307 dihydrochloride 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MRT673071781882-89-0MRT 67307MRT-67307IKKULKAutophagyIκB kinaseI kappa B kinase Unc-51 like kinaseIKKεTBK-1ULK1ULK2autophagysignaltransductioncancerInhibitorinhibitorinhibit

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