2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. Lymphotoxin β Receptor

Lymphotoxin β Receptor  (淋巴毒素-β 受体)

重组蛋白定制服务

淋巴毒素 β 受体（LTBR），又称肿瘤坏死因子受体超家族成员 3 (TNFRSF3)，是肿瘤坏死因子受体超家族成员，参与细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体。LTBR 在大多数细胞类型的表面上表达，包括乳腺癌、结直肠癌、肺癌、胃癌、黑色素瘤和膀胱癌 ，而其配体lymphotoxin (LT) a1b2 和 TNF 超家族成员 14（TNFSF14；也称为 LIGHT)，主要在免疫细胞表面表达 。LTBR 信号通路可参与激活控制细胞分化、生长和死亡的反应，表现为周围淋巴样器官的形成，尤其是二级和三级淋巴结构的形成至关重要，对组织、树突状细胞稳态、肝脏再生、干扰素对病原体的反应和黏膜源性癌的死亡。 LTβR 信号可能会促进浸润性免疫细胞和肿瘤细胞之间的交流。触发 LTβR 可诱导典型和非典型核因子 (NF)-κB 信号传导通路，这些通路与炎症诱导的致癌作用相关。持续的 LTβR 信号传导也导致 NF-κB 介导的慢性炎症和肝细胞癌 (HCC) 的发展[1][2]。

Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a member of the tumor necrosis factor receptor superfamily and a cell surface receptor for lymphotoxins involved in apoptosis and cytokine release. LTBR is expressed on the surface of most cell types, including breast, colorectal, lung, gastric, melanoma, and bladder cancers , while its ligands lymphotoxin (LT) a1b2 and TNF superfamily member 14 (TNFSF14; also known as LIGHT), are mainly expressed on the surface of immune cells. The LTBR signaling pathway may be involved in the activation of responses that control cell differentiation, growth and death, as manifested by the formation of peripheral lymphoid-like organs, especially secondary and tertiary lymphoid structures critical for tissue, dendritic cell homeostasis, liver regeneration, interferon response to pathogens and death in mucosa-derived carcinomas. LTβR signaling may facilitate communication between infiltrating immune cells and tumor cells. Triggering LTβR induces typical and atypical nuclear factor (NF)-κB signaling pathways that are associated with inflammation-induced oncogenic effects. Sustained LTβR signaling also leads to NF-κB-mediated chronic inflammation and the development of hepatocellular carcinoma (HCC)[1][2].

目录号 产品名 / 同用名 种属 表达系统
  • HY-P70345
    TNFRSF3/LTBR Protein, Human (HEK293, His)

    重组人TNFRSF3/LTBR蛋白(HEK293, His)

    rHuTumor necrosis factor receptor superfamily member 3/TNFRSF3, His; Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3

    		Human HEK293
    TNFRSF3/LTBR Protein, Human (HEK293, His) 是一种细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体，参与激活基因转录程序和细胞死亡，在免疫发育和宿主防御中非常重要。TNFRSF3/LTBR Protein, Human (HEK293, His) 是由 HEK293 细胞表达的，是跨膜蛋白（L228-W248），C 端带有 His 标签。
  • HY-P70363
    TNFRSF3/LTBR Protein, Mouse (HEK293, Fc)

    重组小鼠TNFRSF3/LTBR蛋白(HEK293, Fc)

    rMuTumor necrosis factor receptor superfamily member 3/LTBR, Fc; Tumor necrosis factor receptor superfamily member 3; Lymphotoxin-beta receptor; Ltbr; Tnfcr; Tnfrsf3

    		Mouse HEK293
    TNFRSF3/LTBR Protein, Mouse (HEK293, Fc) 是一种细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体，参与激活基因转录程序和细胞死亡，在免疫发育和宿主防御中非常重要。TNFRSF3/LTBR Protein, Mouse (HEK293, Fc) 是由 HEK293 细胞表达的，是跨膜蛋白（L224-W244），C 端带有 Fc 标签。
  • HY-P75918
    TNFRSF3/LTBR Protein, Rat (HEK293, His)

    重组大鼠TNFRSF3/LTBR蛋白(HEK293, His)

    Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3

    		Rat HEK293
    TNFRSF3/LTBR Protein, Rat (HEK293, His) 是一种细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体，参与激活基因转录程序和细胞死亡，在免疫发育和宿主防御中非常重要。TNFRSF3/LTBR Protein, Rat (HEK293, His) 是由 HEK293 细胞表达的，是跨膜蛋白 (M222-W245)，C 端带有 His 标签。
  • HY-P77445
    TNFRSF3/LTBR Protein, Cynomolgus (HEK293, Fc)

    重组猕猴TNFRSF3/LTBR蛋白(HEK293, Fc)

    Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3

    		Cynomolgus HEK293
    TNFRSF3/LTBR Protein, Cynomolgus (HEK293,  Fc) 是一种细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体，参与激活基因转录程序和细胞死亡，在免疫发育和宿主防御中非常重要。TNFRSF3/LTBR Protein, Cynomolgus (HEK293,  Fc) 是由 HEK293 细胞表达的，是跨膜蛋白（M225-W248），C 端带有 His 标签。
  • HY-P72806
    TNFRSF3/LTBR Protein, Human (HEK293, Fc)

    重组人TNFRSF3/LTBR蛋白(HEK293, Fc)

    Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3

    		Human HEK293
    TNFRSF3/LTBR Protein, Human (HEK293, Fc) 是一种细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体，参与激活基因转录程序和细胞死亡，在免疫发育和宿主防御中非常重要。TNFRSF3/LTBR Protein, Human (HEK293, Fc) 是由 HEK293 细胞表达的，是跨膜蛋白（L228-W248），C 端带有 Fc 标签。
  • HY-P75917
    TNFRSF3/LTBR Protein, Rat (HEK293, Fc)

    重组大鼠TNFRSF3/LTBR蛋白(HEK293, Fc)

    Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3

    		Rat HEK293
    TNFRSF3/LTBR Protein, Rat (HEK293,  Fc) 是一种细胞凋亡和细胞因子释放的淋巴毒素的细胞表面受体，参与激活基因转录程序和细胞死亡，在免疫发育和宿主防御中非常重要。TNFRSF3/LTBR Protein, Rat (HEK293,  Fc) 是由 HEK293 细胞表达的，是跨膜蛋白 (M222-W245)，C 端带有 His 标签。
目录号 产品名 作用方式 纯度
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