BAMBI/NMA 蛋白, Human (HEK293, His)

BAMBI/NMA protein operates as a negative regulator, exerting inhibitory control over the TGF-beta signaling pathway. It finely tunes the signaling cascade initiated by TGF-beta, impacting cellular responses like proliferation, differentiation, and immune modulation. This regulatory role emphasizes BAMBI/NMA's significance in modulating diverse cellular behaviors, with potential implications in various physiological and pathological contexts. BAMBI/NMA Protein, Human (HEK293, His) is the recombinant human-derived BAMBI/NMA protein, expressed by HEK293 , with C-His labeled tag. The total length of BAMBI/NMA Protein, Human (HEK293, His) is 132 a.a., with molecular weight of 16-23 kDa.

BAMBI/NMA 蛋白作为 TGF-β 信号传导的负调节因子，对这一重要的细胞通路发挥抑制控制作用。其作用包括调节 TGF-β 引发的信号级联反应，从而影响各种细胞反应。通过负向调节 TGF-β 信号传导，BAMBI/NMA 有助于该途径的微调平衡，影响细胞增殖、分化和免疫调节等过程。这种调节功能强调了该蛋白质在调节细胞行为中的重要性，并强调了其在各种生理和病理环境中的潜在影响。

Human

HEK293

C-6*His

Q13145 (V21-A152)

25805  [NCBI]

VLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAKQARNHSGTTIPTLECCHEDMCNYRGLHDVLSPPRGEASGQGNRYQHDGSRNLITKVQELTSSKELWFRA

Approximately 16-23 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.