2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Epithelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. CD324/E-Cadherin Cadherins
  6. E-Cadherin/Cadherin-1
  7. Cadherin-1/CD324 蛋白, Rat (HEK293, His)

Cadherin-1/CD324 蛋白, Rat (HEK293, His)

目录号: HY-P74367
产品使用指南

Cadherin-1/CD324 蛋白是一种钙依赖性粘附分子，介导细胞过程。它与其他钙粘蛋白分子发生同质相互作用，对细胞类型进行分类和组织。CDH1 调节上皮细胞的粘附、移动性和增殖。它作为整合素配体，抑制侵袭并促进非淀粉样蛋白降解。CDH1 抑制 APP C99 和 C83 的产生。Cadherin-1/CD324 蛋白, Rat (HEK293, His) 是重组的 Cadherin-1/CD324 蛋白，由 HEK293 表达，带有 C-His 标签。Cadherin-1/CD324 蛋白, Rat (HEK293, His) 全长 713 个氨基酸，分子量约为 ~79 kDa。

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描述

Cadherin-1/CD324 protein, a calcium-dependent adhesion molecule, mediates cell processes. It interacts homophilically with other cadherin molecules, sorting and organizing cell types. CDH1 regulates adhesion, mobility, and proliferation of epithelial cells. It serves as an integrin ligand, suppressing invasion and promoting non-amyloidogenic degradation. CDH1 inhibits APP C99 and C83 production. Cadherin-1/CD324 Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-1/CD324 protein, expressed by HEK293, with C-His labeled tag. The total length of Cadherin-1/CD324 Protein, Rat (HEK293, His) is 713 a.a., with molecular weight of ~79 kDa.
研究背景

Cadherin-1/CD324 蛋白是一种钙依赖性细胞粘附分子，在各种细胞过程中发挥着关键作用。通过优先以同种方式与相同类型的其他钙粘蛋白分子相互作用，CDH1 有助于组织内不同细胞类型的分类和组织。此外，它还参与调节上皮细胞的细胞间粘附、移动性和增殖。CDH1 还充当整合素 α-E/β-7 的配体，并在侵袭中表现出有效的抑制作用。此外，它还能促进 Abeta 前体的非淀粉样蛋白降解，并对 APP C99 和 C83 的产生产生强烈的抑制作用。
种属

Rat
表达系统

HEK293
标签

C-His
蛋白编号

Q9R0T4 (M1-A713)
基因 ID

83502  [NCBI]
蛋白结构
N-term
CADH1 (M1-A713)
Accession # Q9R0T4
His
C-term
同用名
Cadherin-1; CDH1; CAM 120/80; E-cadherin; CD324
分子量

Approximately 79 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Cadherin-1/CD324 Protein, Rat (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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