CD96 蛋白, Mouse (HEK293, His)

The CD96 protein plays a key role in immune cell adhesion and promotes PVR interactions on target cells during inflammation. Its role extends to promoting the adhesion of immune cells after crossing the endothelium. CD96 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD96 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD96 Protein, Mouse (HEK293, His) is 515 a.a., with molecular weight of 130-180 kDa.

CD96 蛋白是免疫反应后期粘附相互作用的潜在参与者，特别有助于激活的 T 细胞和 NK 细胞的粘附。它在促进 NK 细胞与靶标粘附方面的作用涉及与靶细胞上存在的 PVR 的相互作用，这表明在炎症过程中免疫细胞与患病细胞的接触中具有功能。所提出的方案意味着 CD96 在 T 细胞和 NK 细胞使用整合素和选择素穿过内皮细胞后发挥作用，积极参与炎症区域内的细胞间相互作用。在结构上，CD96 通过二硫键形成同二聚体并与 PVR 相互作用，强调了其作为免疫细胞粘附过程中关键介质的潜力。进一步探索 CD96 在免疫反应中的精确机制和动态，可以为了解其在炎症和免疫监视过程中协调细胞相互作用的作用提供有价值的见解。

Mouse

HEK293

C-6*His

Q3U0X8 (V22-M536)

84544  [NCBI]

VWEELFNVGDDVYALPGSDINLTCQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWTLYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEPYTQDEHNYTIEIETNRTLEIPCFQNTSSEIPPRFTFSWLVEKDGVEEVLFTHHHHVNNSTSFKGRIRLGGDYRLHLSPVQIQDDGRTFSCHLTVNPLKAWKMSTTVKVFAKPEILMTVENSTMDVLGERVFTCLLKNVFPKANITWFIDGRFLQGNEEGIYITNEEKNCSSGFWELKSVLTRMHSGPSQSNNMTAWCMALSPGPRNKMWNTSSQPITVSFDSVIAPTKHLPTVTGSTLGTQPFSDAGVSPTGYLATPSVTIVDENGLTPDATPQTSNSSMTTKDGNYLEASSGTDAKNSSRAAASSKSGSWPFPFTSPPEWHSLPGTSTGPQEPDSPVSWIPSEVHTSAPLDASLAPHDTIISTTTEFPNVLTTANGTTKIDHGPITSIIVNQPSDGM

130-180 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.