1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Peptide Hormone & Neuropeptides
  4. Gastric Inhibitory Peptide (GIP)
  5. GIP 蛋白, Mouse (HEK293, Fc)

GIP 蛋白, Mouse (HEK293, Fc)

目录号: HY-P77949
产品使用指南

GIP 蛋白是胰岛素分泌的有效刺激剂,可通过促进胰腺 β 细胞释放胰岛素来严格调节葡萄糖稳态。GIP对胃酸分泌的抑制作用有限,在营养感知和代谢调节中发挥双重作用,特别是在餐后葡萄糖代谢中。GIP 蛋白, Mouse (HEK293, Fc) 是重组的 GIP 蛋白,由 HEK293 表达,带有 C-hFc 标签。GIP 蛋白, Mouse (HEK293, Fc) 全长 64 个氨基酸,分子量为 40-45 kDa。

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描述

GIP protein is a potent stimulator of insulin secretion that critically regulates glucose homeostasis by promoting insulin release from pancreatic beta cells. GIP has limited inhibitory effects on gastric acid secretion and plays dual roles in nutrient sensing and metabolic regulation, particularly in postprandial glucose metabolism. GIP Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GIP protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GIP Protein, Mouse (HEK293, Fc) is 64 a.a., with molecular weight of 40-45 kDa.

研究背景

GIP 蛋白作为胰岛素分泌的有效刺激剂,在葡萄糖稳态中发挥着至关重要的作用。其主要功能在于促进胰腺β细胞释放胰岛素,有助于调节血糖水平。相比之下,GIP对胃酸分泌的抑制作用相对有限。这种双重作用使 GIP 成为营养传感和代谢调节之间复杂相互作用的关键参与者,特别是在餐后葡萄糖代谢的背景下。该蛋白质增强胰岛素分泌的能力强调了其在控制葡萄糖代谢中的重要性,使其成为理解和潜在调节与糖尿病和胰岛素抵抗相关的代谢过程的感兴趣的目标。

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

P48756 (E22-Q85)

基因 ID

14607  [NCBI]

蛋白结构
N-term
GIP (E22-Q85)
Accession # P48756
hFc
C-term
同用名
GIP; Incretin
分子量

40-45 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
GIP Protein, Mouse (HEK293, Fc)
目录号:
HY-P77949
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