NKG2C-CD94 Heterodimer 蛋白, Human (HEK293, His-Avi)

NKG2C/CD159c Protein, an immune activating receptor, crucially contributes to self-nonself discrimination. Partnering with KLRD1, it recognizes non-classical MHC class Ib HLA-E loaded with peptides from HLA-G, impacting adaptive NK cell functions and maternal-fetal tolerance. NKG2C/CD159c regulates terminally differentiated cytotoxic lymphocytes, particularly in adaptive NK cell responses to viral infection. Upon binding to HLA-E-peptide complexes, it transmits intracellular signals via TYROBP/DAP12, initiating cell activation. The multifaceted interactions highlight its essential role in immune responses and self-tolerance mechanisms. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi), has molecular weight of 30-50 kDa.

NKG2C/CD159c 蛋白是一种免疫激活受体，在自我-非自我辨别中发挥着关键作用。它与细胞毒性淋巴细胞亚群上的 KLRD1 合作，识别装载有来自非经典 MHC Ib 类 HLA-G 分子的信号序列衍生肽的非经典主要组织相容性 (MHC) Ib 类 HLA-E。这种相互作用可能有助于适应性自然杀伤（NK）细胞的产生和效应功能，并与妊娠期间母胎耐受性有关。NKG2C/CD159c 还调节终末分化的细胞毒性淋巴细胞亚群的效应功能，特别是在对病毒感染的适应性 NK 细胞反应中。与 HLA-E 肽复合物结合后，NKG2C/CD159c 通过衔接蛋白 TYROBP/DAP12 传递细胞内信号，启动近端信号分子的磷酸化和随后的细胞激活。KLRD1-KLRC2 受体复合物通过二硫键与 KLRD1 形成异二聚体，与 TYROBP 同二聚体结合，对其细胞表面表达至关重要。此外，该受体复合物可以以低亲和力与负载有源自经典 MHC Ia 类信号序列的自身肽的 HLA-E 结合。NKG2C/CD159c 的多方面相互作用和功能强调了其在免疫反应和自我耐受机制中的重要作用。

Human

HEK293

N-His;N-Avi

P26717 (E98-L231)&Q13241 (S34-I179)

3822  [NCBI]&3824  [NCBI]

30-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.