2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Ubiquitination-IN-2

Ubiquitination-IN-2 是一种有效的 E1-E2 蛋白-蛋白相互作用 (PPI) 抑制剂。Ubiquitination-IN-2 对于泛素 E1 (UBA1) 的 Kd 值为 0.72 μM。Ubiquitination-IN-2 抑制泛素从 E1 到 E2 的转移。Ubiquitination-IN-2 可用于癌症研究。

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Ubiquitination-IN-2 Chemical Structure

Ubiquitination-IN-2 Chemical Structure

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Ubiquitination-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ubiquitination-IN-2 is a potent E1-E2 protein−protein interactions (PPI) inhibitor. Ubiquitination-IN-2 has a Kd value of 0.72 μM for ubiquitin E1 (Uba1). Ubiquitination-IN-2 inhibits blocks ubiquitin transfer from E1 to E2. Ubiquitination-IN-2 can be used in research of cancer[1].

体外研究
(In Vitro)

Ubiquitination-IN-2 (M1-S1; 0-50 μM; 16 h; HEK293T 细胞) 通过阻断 CHIP 催化的单泛素化来抑制泛素向底物蛋白 CDK4 的转移[1] 。
Ubiquitination-IN-2 (0-50 μM; HEK293T 细胞) 通过与 E1 酶 Uba1 结合并阻断从 E1 到 E2 的泛素转移来抑制蛋白质泛素化级联[1]。
Ubiquitination-IN-2 (0-50 μM; HEK293T 细胞) 抑制泛素转移到不同类型的 E2 酶，在 50 μM 浓度下抑制 E2-UB 结合物的形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ubiquitination-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0, 10, 50 μM
Incubation Time: 16 hours
Result: Inhibitd the ubiquitination of CDK4 in HEK293T cells.
分子量

2346.04

Formula

C93H173N25O28S8
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ubiquitination-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ubiquitination-IN-2E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseUba1Uba2transferHEK293T cellscancerubiquitinInhibitorinhibitorinhibit

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