2. Immunology/Inflammation
  3. PGE synthase
  4. UK4b

UK4b 是一种高选择性的微粒体型前列腺素 E2 合成酶-1 (mPGES-1) 抑制剂。UK4b 具有抗炎和镇痛作用。UK4b 在小鼠体内可以阻断腹主动脉瘤的生长。

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UK4b Chemical Structure

UK4b Chemical Structure

CAS No. : 2171000-87-4

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UK4b 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice[1].

体内研究
(In Vivo)

UK4b (10-20 mg/kg; s.c.;一天两次连续 22 天) 能阻断 ApoE−/−血管紧张素 (Ang) II (1000 ng/kg/min; 输注,连续 28 天) 诱导的腹主动脉瘤 (AAA) 小鼠模型中腹主动脉瘤 (AAA) 的进一步生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

404.89

Formula

C21H25ClN2O4
CAS 号
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UK4b 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK4b2171000-87-4PGE synthaseProstaglandin E synthaseAbdominal aortic aneurysm (AAA)anti-inflammatoryease painInhibitorinhibitorinhibit

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