2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK
  4. Y-27632 dihydrochloride

Y-27632 dihydrochloride (GMP) 是 Y-27632 dihydrochloride (HY-10583) 的 GMP 级别。GMP 指南用于生产 Y-27632 dihydrochloride (GMP) 。GMP 小分子可作为细胞研究生产的辅助试剂。Y-27632 dihydrochloride 是一种 ATP 竞争性的 ROCK 抑制剂，具有口服活性。Y-27632 dihydrochloride (GMP) 具有抗癫痫作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Y-27632 dihydrochloride Chemical Structure

Y-27632 dihydrochloride Chemical Structure

CAS No. : 129830-38-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mg ￥12800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Y-27632 dihydrochloride:

Y-27632 dihydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 243 篇科研文献

WB
IF

    Y-27632 dihydrochloride purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583.  [Abstract]

    Expression of CTC cluster-related (plakoglobin and CD44) and EMT-related (vimentin and E-cadherin, 4 days) proteins in LNCaP cells grown on different substrates after treatment with different inhibitors (Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl)).

    Y-27632 dihydrochloride purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583.  [Abstract]

    Immunofluorescence imaging of LNCaP cells treated with the Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl). After the cells are cultured on different substrates for 3 days, inhibitors are added and incubated for 24 h.

    Y-27632 dihydrochloride purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 Jun 28;37(1):128.  [Abstract]

    MHCC-97H and Huh-7 cells co-transfected with control or supervillin-specific siRNA and a RhoA(WT), RhoA(V14), or RhoA(N19) plasmids for 48 h are treated with PBS or Y27632 2HCl (10 μM) for 16 h during hypoxia, and then assayed for phosphorylated p38 and ERK by immunoblotting. β-actin is used as the loading control

    Y-27632 dihydrochloride purchased from MCE. Usage Cited in: Oncotarget. 2017 Jul 31;8(47):82506-82530.  [Abstract]

    SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) cells were either untreated (-) or treated (+) with 10mM Y27632 over a period of 48 hr. SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) clones were either untreated (-) or treated (+) with 10 mM Y27632 followed by stimulation without (-) or with (+) 5 ng/mL of TGFβ1 for 48 hr.

    查看 ROCK 亚型特异性产品:

    查看所有亚型
    ROCK ROCK1 ROCK2

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect[1][2][3][4].

    体外研究
    (In Vitro)

    Y-27632 dihydrochloride (GMP) (2 μM; 4-8 d) 可提高直接转化为神经元细胞的小鼠成纤维细胞的存活率并增加重编程[1]。
    Y-27632 dihydrochloride (GMP) 诱导人成纤维细胞转化为功能性心肌细胞[2]。
    Y-27632 dihydrochloride (GMP) 诱导成纤维细胞转化为多能干细胞（hiPSCs）[2]。
    Y-27632 dihydrochloride (GMP) (2-10 μM) 促进人 EPS 细胞增殖并诱导 primed hPSCs 转化为 hEPS 细胞[3]。
    Y-27632 dihydrochloride (GMP) (10 μM) 诱导从囊胚衍生的人 EPS 细胞[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Y-27632 dihydrochloride 相关抗体:
    分子量

    320.26

    Formula

    C14H23Cl2N3O
    CAS 号
    非标记 CAS

    性状

    粉末

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 100 mg/mL (312.25 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.1225 mL 15.6123 mL 31.2246 mL
    5 mM 0.6245 mL 3.1225 mL 6.2449 mL
    查看完整储备液配制表

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料
    参考文献

    Y-27632 dihydrochloride 相关分类

    完整储备液配制表

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.1225 mL 15.6123 mL 31.2246 mL 78.0616 mL
    5 mM 0.6245 mL 3.1225 mL 6.2449 mL 15.6123 mL
    10 mM 0.3122 mL 1.5612 mL 3.1225 mL 7.8062 mL
    15 mM 0.2082 mL 1.0408 mL 2.0816 mL 5.2041 mL
    20 mM 0.1561 mL 0.7806 mL 1.5612 mL 3.9031 mL
    25 mM 0.1249 mL 0.6245 mL 1.2490 mL 3.1225 mL
    30 mM 0.1041 mL 0.5204 mL 1.0408 mL 2.6021 mL
    40 mM 0.0781 mL 0.3903 mL 0.7806 mL 1.9515 mL
    50 mM 0.0624 mL 0.3122 mL 0.6245 mL 1.5612 mL
    60 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3010 mL
    80 mM 0.0390 mL 0.1952 mL 0.3903 mL 0.9758 mL
    100 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7806 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Y-27632 dihydrochloride (GMP)129830-38-2ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKantiepileptic effectadipose tissue-derived stem cellsADSCsGMPInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Y-27632 dihydrochloride
    目录号：
    HY-10583G
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z