1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3
  3. 1-Azakenpaullone

1-Azakenpaullone (Synonyms: 1-Akp)

目录号: HY-59090
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1-Azakenpaullone (1-Akp) 是具有高度选择性的、ATP 竞争性的糖原合成酶激酶3 β (GSK-3β) 的抑制剂,其IC50 值为 18 nM。

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1-Azakenpaullone Chemical Structure

1-Azakenpaullone Chemical Structure

CAS No. : 676596-65-9

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Description

1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].

IC50 & Target[1]

GSK-3β

18 nM (IC50)

CDK1/cyclin B

2 μM (IC50)

CDK5/p25

4.2 μM (IC50)

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (190.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0473 mL 15.2365 mL 30.4729 mL
5 mM 0.6095 mL 3.0473 mL 6.0946 mL
10 mM 0.3047 mL 1.5236 mL 3.0473 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
References
Molecular Weight

328.16

Formula

C₁₅H₁₀BrN₃O

CAS No.

676596-65-9

SMILES

O=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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