2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Rilmazafone hydrochloride

Rilmazafone hydrochloride  (Synonyms: 450191S)

目录号: HY-U00228 纯度: 99.75%
COA 产品使用指南

摩尔计算器

Rilmazafone hydrochloride (450191S) 是一种苯二氮卓类 ω 配体。

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Rilmazafone hydrochloride Chemical Structure

Rilmazafone hydrochloride Chemical Structure

CAS No. : 85815-37-8

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规格 价格 是否有货 数量
5 mg ￥500
In-stock
10 mg ￥800
In-stock
25 mg ￥1700
In-stock
50 mg ￥2900
In-stock
100 mg ￥4800
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Rilmazafone hydrochloride:

Rilmazafone hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rilmazafone hydrochloride (450191S) is a benzodiazepine (omega) ligand[1].

体内研究
(In Vivo)

When the animals are pretreated with high doses of Rilmazafone hydrochloride (450191-S; 200 or 600 mg/kg for 5 or 3 days, respectively) to induce hepatic drug-metabolizing enzymes, plasma concentrations of the metabolites after oral administration of a dose of 200 mg/kg of Rilmazafone decrease markedly depending on the induced enzyme activity. Pretreatment of rats with phenobarbital also causes decreased plasma levels of metabolites, which are almost the same as those in Rilmazafone-pretreatment. On the other hand, administration of beta-naphthoflavone to rats leads to higher plasma levels of metabolites, and slower elimination compared with those in the control and Rilmazafone or Phenobarbital pretreated rats. Rilmazafone is demonstrated to stimulate the hepatic drug-metabolizing enzymes in rats, mice and dogs, which is accompanied by a marked reduction in the pharmacological activity of pentobarbital in rats. The induction of hepatic enzyme activities by Rilmazafone is detected only when the plasma concentrations of its metabolites are very high[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

511.79

Formula

C21H21Cl3N6O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

利马扎封盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (488.48 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9539 mL 9.7696 mL 19.5393 mL
5 mM 0.3908 mL 1.9539 mL 3.9079 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[2]

Mice[2]
Adult male rats of the Jcl Sprague-Dawley strain, 7-8 weeks old, are used for the experiments. The animals are kept in an air-conditioned room (25±1°C, 50-60% humidity) lighted 12 hr a day (8:00-20:00) and maintain on com mercial rat chow and water ad libitum. Rilmazafone is dissolved in 5% (w/v) arabic gum at 20 or 60 mg/mL, and the resulting solution is administered orally to rats at 1.0 mL/100 g body weight for 3-5 days. Typical inducers, phenobarbital (in physiological saline) and beta-naphthoflavone (in sesame oil), are administered intraperitoneally at a dose of 40 mg/kg, once daily for 3 days. The animals are fasted for 24 hr after the last adminis tration of Rilmazafone or inducers, and then the test solution of Rilmazafone (20 mg/mL of 5% arabic gum) is given orally to rats at a dose of 200 mg/kg. Heparinized blood samples are obtained from the abdominal aorta under ether anesthesia and centrifuged immediately to obtain plasma samples using an Eppendorf centrifuge Type 5414S.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Rilmazafone hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9539 mL 9.7696 mL 19.5393 mL 48.8482 mL
5 mM 0.3908 mL 1.9539 mL 3.9079 mL 9.7696 mL
10 mM 0.1954 mL 0.9770 mL 1.9539 mL 4.8848 mL
15 mM 0.1303 mL 0.6513 mL 1.3026 mL 3.2565 mL
20 mM 0.0977 mL 0.4885 mL 0.9770 mL 2.4424 mL
25 mM 0.0782 mL 0.3908 mL 0.7816 mL 1.9539 mL
30 mM 0.0651 mL 0.3257 mL 0.6513 mL 1.6283 mL
40 mM 0.0488 mL 0.2442 mL 0.4885 mL 1.2212 mL
50 mM 0.0391 mL 0.1954 mL 0.3908 mL 0.9770 mL
60 mM 0.0326 mL 0.1628 mL 0.3257 mL 0.8141 mL
80 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6106 mL
100 mM 0.0195 mL 0.0977 mL 0.1954 mL 0.4885 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rilmazafone85815-37-8450191S利马扎封盐酸盐GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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