1. Steroids

5α-Pregnane-3β,6α-diol-20-one 

目录号: HY-109564 纯度: >98.0%
产品使用指南

5α-Pregnane-3β,6α-diol-20-one 是一种促进有丝分裂的 progesterone 代谢物,可于血清不足时雄性激素反应的前列腺素癌细胞中产生。

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5α-Pregnane-3β,6α-diol-20-one Chemical Structure

5α-Pregnane-3β,6α-diol-20-one Chemical Structure

CAS No. : 21853-11-2

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Description

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

In Vitro

Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts[1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity[2].

References
Molecular Weight

334.49

Formula

C₂₁H₃₄O₃

CAS No.

21853-11-2

SMILES

C[C@@]12[C@]3([H])[C@](C[C@H](O)[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@@H](C(C)=O)CC4)CC3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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产品名称:
5α-Pregnane-3β,6α-diol-20-one
目录号:
HY-109564
需求量: