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  3. 8-Bromo-cAMP sodium salt

8-Bromo-cAMP sodium salt (Synonyms: 8-Br-Camp sodium salt)

目录号: HY-12306 纯度: 98.52%
产品使用指南

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) 是一种环 AMP 类似物,是一种环 AMP 依赖性蛋白激酶 (PKA) 激活剂。

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8-Bromo-cAMP sodium salt Chemical Structure

8-Bromo-cAMP sodium salt Chemical Structure

CAS No. : 76939-46-3

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥660 In-stock
5 mg ¥600 In-stock
10 mg ¥800 In-stock
25 mg ¥1600 In-stock
50 mg ¥2200 In-stock
100 mg ¥3300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA)[1].

IC50 & Target

PKA[1]

In Vitro

8-Bromo-cAMP sodium salt is a brominated derivative of cyclic AMP. 8-Bromo-cAMP sodium salt enhances the efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium salt inhibits proliferation, induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109)[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (290.64 mM; Need ultrasonic)

H2O : ≥ 33.33 mg/mL (77.50 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3251 mL 11.6257 mL 23.2515 mL
5 mM 0.4650 mL 2.3251 mL 4.6503 mL
10 mM 0.2325 mL 1.1626 mL 2.3251 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

430.08

Formula

C₁₀H₁₀BrN₅NaO₆P

CAS No.

76939-46-3

SMILES

BrC1=NC2=C(N=CN=C2N)N1[C@H](O[C@@](CO3)([H])[C@@]4([H])OP3(O[Na])=O)[C@@H]4O

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
8-Bromo-cAMP sodium salt
目录号:
HY-12306
需求量:

8-Bromo-cAMP sodium salt

Cat. No.: HY-12306