1. Anti-infection
  2. Bacterial
    Parasite

ABBV-4083 

目录号: HY-111757
产品使用指南

ABBV-4083 是Tylosin A 的类似物,具有强大的抗 Wolbachia 和 抗丝虫活性。

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ABBV-4083 Chemical Structure

ABBV-4083 Chemical Structure

CAS No. : 1809266-03-2

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Description

ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1].

In Vivo

ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti[1].

Animal Model: Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites[1].
Dosage: 150 mg/kg
Administration: PO once daily for 14 days started at 14 weeks post infection.
Result: Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reduced by >99.9% in the recovered female adult worms.
Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
References
Molecular Weight

1024.21

Formula

C₅₃H₈₂FNO₁₇

CAS No.

1809266-03-2

SMILES

O[C@@H]1[C@@H](C)O[C@](OC[C@H]([C@@H](CC)OC(C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]2C)O[C@]3([H])O[C@H](C)[C@@H](O[C@]4([H])O[C@@H](C)[C@H](OCC5=CC=C(F)C=C5)[C@@](O)(C)C4)[C@H](N(C)C)[C@H]3O)C)O)=O)/C=C(C)/C=C/C2=O)([H])[C@H](OC)[C@@H]1OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
ABBV-4083
目录号:
HY-111757
需求量:

ABBV-4083

Cat. No.: HY-111757