1. Anti-infection
  2. Bacterial
    Parasite
  3. ABBV-4083

ABBV-4083 

目录号: HY-111757
产品使用指南

ABBV-4083 是Tylosin A 的类似物,具有强大的抗 Wolbachia 和 抗丝虫活性。

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ABBV-4083 Chemical Structure

ABBV-4083 Chemical Structure

CAS No. : 1809266-03-2

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Description

ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1].

In Vivo

ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti[1].

Animal Model: Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites[1].
Dosage: 150 mg/kg.
Administration: PO once daily for 14 days started at 14 weeks post infection (pti).
Result: Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reduced by >99.9% in the recovered female adult worms.
Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1024.21

Formula

C₅₃H₈₂FNO₁₇

CAS No.

1809266-03-2

SMILES

O[C@@H]1[C@@H](C)O[C@](OC[C@H]([C@@H](CC)OC(C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]2C)O[C@]3([H])O[C@H](C)[C@@H](O[C@]4([H])O[C@@H](C)[C@H](OCC5=CC=C(F)C=C5)[C@@](O)(C)C4)[C@H](N(C)C)[C@H]3O)C)O)=O)/C=C(C)/C=C/C2=O)([H])[C@H](OC)[C@@H]1OC

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
ABBV-4083
目录号:
HY-111757
需求量:

ABBV-4083

Cat. No.: HY-111757