1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

ACY-1083 

目录号: HY-111791
产品使用指南

ACY-1083 是一种可渗透脑的选择性 HDAC6 抑制剂,IC50 为 3 nM,ACY-1083 对 HDAC6 的选择性比其他类别的 HDAC 亚型高 260 倍。ACY-1083 可有效逆转化疗引起的周围神经病变。

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ACY-1083 Chemical Structure

ACY-1083 Chemical Structure

CAS No. : 1708113-43-2

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Description

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].

IC50 & Target[1]

HDAC6

3 nM (IC50)

References
Molecular Weight

348.35

Formula

C₁₇H₁₈F₂N₄O₂

CAS No.

1708113-43-2

SMILES

FC(CC1)(F)CCC1(NC2=NC=C(C(NO)=O)C=N2)C3=CC=CC=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
ACY-1083
目录号:
HY-111791
需求量:

ACY-1083

Cat. No.: HY-111791