1. PI3K/Akt/mTOR
  2. Akt
  3. AKT-IN-2

AKT-IN-2 

目录号: HY-112148
产品使用指南

AKT-IN-2 是一种有效的,选择性和口服生物可利用的 AKT 抑制剂,抑制 AKT1IC50 为 5 nM。

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AKT-IN-2 Chemical Structure

AKT-IN-2 Chemical Structure

CAS No. : 1295514-91-8

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Description

AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1[1].

IC50 & Target[1]

Akt1

5 nM (IC50)

P70S6K

399 nM (IC50)

PKA

84 nM (IC50)

PKCβ2

3.98 μM (IC50)

RSK1

568 nM (IC50)

pGSK3β

92 nM (IC50)

In Vitro

AKT-IN-2 (Compound 8) also inhibits P70S6K, PKA, PKCβ2, RSK1, and pGSK3β with IC50s of 0.399, 0.084, 3.98, 0.568, and 0.092 μM, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

505.58

Formula

C₂₅H₃₄F₃N₇O

CAS No.

1295514-91-8

SMILES

O=C1C[C@@H](C)C2=C(N3CCC(C4=NC(CCC(F)(F)F)=CN4CCN5CCCC5)CC3)N=CN=C2N1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
AKT-IN-2
目录号:
HY-112148
需求量:

AKT-IN-2

Cat. No.: HY-112148