1. GPCR/G Protein
  2. MCHR1 (GPR24)

ALB-127158(a) 

目录号: HY-111398 纯度: 99.32%
产品使用指南

ALB-127158(a) 是一种有效的选择性黑色素浓缩激素 1 (MCH1) 受体拮抗剂。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务
ALB-127158(a) Chemical Structure

ALB-127158(a) Chemical Structure

CAS No. : 1173154-32-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥2310 In-stock
5 mg ¥2100 In-stock
10 mg ¥3300 In-stock
25 mg ¥6500 In-stock
50 mg ¥11000 In-stock
100 mg ¥18000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products

ALB-127158(a) 相关产品

Related Screening Libraries:

  • 生物活性

  • 实验参考方法

  • 技术信息

  • 纯度 & 产品资料

  • 参考文献

Description

ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist.

IC50 & Target

MCH1 receptor[1]

In Vitro

ALB-127158(a) has high affinity for the MCH1 receptor (7 nM) with good selectivity over a range of other G-protein coupled receptors (GPCRs), ion channels and transporters, including the MCH2 receptor. In vitro functional assays confirmed that ALB-127158(a) is a potent and selective MCH1 receptor antagonist[1].

In Vivo

In a mouse diet induced obesity (DIO) model, ALB-127158(a) produces a significant sustained decrease in body weight and food intake in the range of 5-15 mg/kg bid. The weight reduction is predominantly due to a decrease in fat content. In high fat diet (HFD) rats, ALB-127158(a) produces significant weight loss and food reduction at doses as low as 1.25 mg/kg po. Doses > 1.25 mg/kg po produces weight loss > 6%, maximal weight loss of about 10% in rats is observed at 10 mg/kg. Following single and multiple oral administration of ALB-127158(a), ALB-127158(a) is rapidly absorbed (median tmax attains between 1 and 3 h post dose in lean and overweight/obese subjects) with a trend to decrease over dose suggesting a slower absorption rate of ALB-127158(a) at lower doses. After single doses, ALB-127158(a) has a mean half-life (t1/2) of 18 to 21 h. Slightly longer mean t1/2 estimates of approximately 26 h are obtained following multiple dosing in overweight/obese subjects; steady-state plasma ALB-127158(a) is attained within 6 to 8 days of dosing[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4726 mL 12.3628 mL 24.7255 mL
5 mM 0.4945 mL 2.4726 mL 4.9451 mL
10 mM 0.2473 mL 1.2363 mL 2.4726 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

404.44

Formula

C₂₃H₂₁FN₄O₂

CAS No.

1173154-32-9

SMILES

O=C1C=C(OCC2=NC=C(F)C=C2)C=CN1C3=CC4=C(C=C3)C(CNCC5)=C5N4C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
ALB-127158(a)
目录号:
HY-111398
需求量: