2. JAK/STAT Signaling Autophagy Apoptosis
  3. Pim Autophagy Apoptosis
  4. AZD1208 hydrochloride

AZD1208 hydrochloride 是一种有效的，具有口服活性的，具有高度选择性的 PIM 抑制剂。

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AZD1208 hydrochloride Chemical Structure

AZD1208 hydrochloride Chemical Structure

CAS No. : 1621866-96-3

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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AZD1208 hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of AZD1208 hydrochloride:

AZD1208 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor[1].

IC50 & Target

PIM[1]
体外研究
(In Vitro)

AZD1208 hydrochloride shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 hydrochloride (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cells at 1 μM. AZD1208 hydrochloride induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 hydrochloride and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZD1208 hydrochloride 相关抗体:
Clinical Trial
分子量

415.94

Formula

C21H22ClN3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 83.3 mg/mL (200.27 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4042 mL 12.0210 mL 24.0419 mL
5 mM 0.4808 mL 2.4042 mL 4.8084 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[1]

MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound (including AZD1208 hydrochloride) or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37˚C and reading of fluorescence on a Tecan Infinite® 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

AZD1208 hydrochloride 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4042 mL 12.0210 mL 24.0419 mL 60.1048 mL
5 mM 0.4808 mL 2.4042 mL 4.8084 mL 12.0210 mL
10 mM 0.2404 mL 1.2021 mL 2.4042 mL 6.0105 mL
15 mM 0.1603 mL 0.8014 mL 1.6028 mL 4.0070 mL
20 mM 0.1202 mL 0.6010 mL 1.2021 mL 3.0052 mL
25 mM 0.0962 mL 0.4808 mL 0.9617 mL 2.4042 mL
30 mM 0.0801 mL 0.4007 mL 0.8014 mL 2.0035 mL
40 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5026 mL
50 mM 0.0481 mL 0.2404 mL 0.4808 mL 1.2021 mL
60 mM 0.0401 mL 0.2003 mL 0.4007 mL 1.0017 mL
80 mM 0.0301 mL 0.1503 mL 0.3005 mL 0.7513 mL
100 mM 0.0240 mL 0.1202 mL 0.2404 mL 0.6010 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD12081621866-96-3AZD 1208AZD-1208PimAutophagyApoptosisPim kinasesInhibitorinhibitorinhibit

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产品名称：
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