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  3. AZD9567

AZD9567 

目录号: HY-120012 纯度: >99.0%
产品使用指南

AZD9567 (compound 15) 是一种有效的、具有口服活性的、非甾体类的、选择性糖皮质激素受体调节剂 (SGRM), 其 IC50 值为 3.8 nM。对 SCW 联合炎症表现出良好的疗效。

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AZD9567 Chemical Structure

AZD9567 Chemical Structure

CAS No. : 1893415-00-3

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥7150 In-stock
5 mg ¥6500 In-stock
10 mg ¥9500 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].

IC50 & Target

IC50: 3.8 nM (Glucocorticoid receptor)[1].

In Vivo

AZD9567 (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation[1].

Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW[1].
Dosage: 15 mg/kg/day.
Administration: Oral gavage daily for 8 days.
Result: Inhibited ankle swelling in the rat SCW model.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

References
Molecular Weight

494.53

Formula

C₂₇H₂₈F₂N₄O₃

CAS No.

1893415-00-3

SMILES

CC(F)(F)C(N[C@H]([C@H](OC1=CC2=C(N(C(C=C3)=CN(C)C3=O)N=C2)C=C1)C4=CC=CC=C4)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
AZD9567
目录号:
HY-120012
需求量:

AZD9567

Cat. No.: HY-120012