1. GPCR/G Protein
  2. Leukotriene Receptor

Amelubant (Synonyms: BIIL 284)

目录号: HY-19304
产品使用指南

Amelubant (BIIL 284) 是一种有效、可口服、长效的 LTB4 receptor 拮抗剂,对 LTB4 受体的结合亲和性很低,在细胞和细胞膜中,Ki 值分别为 221 nM 和 230 nM。Amelubant (BIIL 284) 是活性代谢物 BIIL 260 和 BIIL 315 的前体。具有抗炎活性。

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Amelubant Chemical Structure

Amelubant Chemical Structure

CAS No. : 346735-24-8

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Description

Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1].

IC50 & Target[1]

LTB4

221 nM (Ki, in vital human granulocytes)

LTB4

230 nM (Ki, in cell membranes)

In Vitro

Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively[1].

References
Molecular Weight

538.63

Formula

C₃₃H₃₄N₂O₅

CAS No.

346735-24-8

SMILES

CC(C1=CC=C(OCC2=CC(COC3=CC=C(C(NC(OCC)=O)=N)C=C3)=CC=C2)C=C1)(C4=CC=C(O)C=C4)C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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× = ×
C1   V1   C2   V2

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产品名称:
Amelubant
目录号:
HY-19304
需求量:

Amelubant

Cat. No.: HY-19304