1. Membrane Transporter/Ion Channel
  2. Monocarboxylate Transporter

BAY-8002 

目录号: HY-122312
产品使用指南

BAY-8002 是一种有效、选择性、可口服的单羧酸转运蛋白第 1 亚型 (monocarboxylate transporter 1 (MCT1)) 抑制剂,在表达 MCT1 的 DLD-1 细胞中,IC50 值为 85 nM,对 MCT1 的选择性远高于 MCT4。具有抗肿瘤活性。

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BAY-8002 Chemical Structure

BAY-8002 Chemical Structure

CAS No. : 724440-27-1

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Description

BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity[1].

IC50 & Target

IC50: 85 nM (MCT1, in DLD-1 cells)[1]

In Vitro

BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 µM in EVSA-T cells)[1].

References
Molecular Weight

415.85

Formula

C₂₀H₁₄ClNO₅S

CAS No.

724440-27-1

SMILES

O=C(O)C1=CC=CC=C1NC(C2=CC(S(=O)(C3=CC=CC=C3)=O)=CC=C2Cl)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
BAY-8002
目录号:
HY-122312
需求量:

BAY-8002

Cat. No.: HY-122312