1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. BSc5371

BSc5371 是一种有效的、不可逆的 FLT3 抑制剂,对 FLT3 突变体 FLT3(D835H),FLT3(ITD, D835V),FLT3(ITD, F691L),FLT3-ITD 和野生型 FLT3wt 的 Kd 值分别为 1.3,0.83,1.5,5.8 和 2.3 nM。BSc5371 对 FLT3 依赖性的细胞具有细胞毒性。

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BSc5371 Chemical Structure

BSc5371 Chemical Structure

CAS No. : 2286419-03-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines[1].

IC50 & Target

Kd: 1.3 nM (LT3(D835H)), 0.83 nM (LT3(ITD, D835V)), 1.5 nM (LT3(ITD, F691L)), 5.8 nM (FLT3-ITD), 2.3 nM (FLT3wt)[1]

体外研究
(In Vitro)

BSc5371 (5 μM-0.5 nM, 77 hours) exhibits inhibitory activity against FLT3-mutated (MV4-11) cells, with an IC50 of 6 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MV4-11 cells
Concentration: 0.5 nM, 2.5 nM, 5 nM, 25 nM, 50 nM, 250 nM, 500 nM and 5 μM
Incubation Time: 77 hours
Result: Exhibited inhibitory activity against MV4-11 cells, with an IC50 of 6 nM.
分子量

485.60

Formula

C24H31N5O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

BSc5371 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BSc5371
目录号:
HY-111545
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