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Ipramidil  (Synonyms: 异丙地尔; C80-1324)

目录号: HY-U00172
COA 产品使用指南

Ipramidil (C80-1324) 是一种呋咱环化合物。在离体心脏的冠脉循环中具有显著的扩张活性。

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Ipramidil Chemical Structure

Ipramidil Chemical Structure

CAS No. : 83656-38-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ipramidil (C80-1324) is a furoxan compound. Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.

体外研究
(In Vitro)

The vasodilator action of Ipramidil (C80-1324) on coronary vessels is more potent than that of GTN and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by glyceryl trinitrate (GTN) is blunted upon coinfusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL,which induces an increase in coronary flow of 67±9% (N=5). Moreover, the vasodilatoreffect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance (P=0.493, N=3). However,when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished (P=0.006, N=3). Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

256.26

Formula

C10H16N4O4

CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

异丙地尔

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Ipramidil 相关分类

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