1. GPCR/G Protein
  2. Prostaglandin Receptor

CAY10471 Racemate (Synonyms: TM30089 Racemate)

目录号: HY-13706 纯度: 99.35%
产品使用指南

CAY10471 Racemate (TM30089 Racemate) 是一种有效、高度选择性的前列腺素 D2 受体 (CRTH2) 拮抗剂,对 hCRTH2 的 Ki 值为 0.6 nM,对其选择性远高于人血栓素 A2 受体 TP (Ki,>10000 nM) 或 PGD2 受体 DP (Ki,1200 nM)。CAY10471 Racemate 对小鼠和大鼠的同源 CRTH2 也具有拮抗作用。

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CAY10471 Racemate Chemical Structure

CAY10471 Racemate Chemical Structure

CAS No. : 844639-57-2

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥1210 In-stock
5 mg ¥1100 In-stock
10 mg ¥1800 In-stock
25 mg ¥3900 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].

IC50 & Target

Ki: 0.6 nM (CRTH2), 1200 nM (DP)[1]

In Vitro

CAY10471 Racemate (Compound 13) inhibits PGD2-induced inositol phosphate or cAMP formation, suppresses β-arrestin translocation with IC50s of 12 and 3 nM, respectively[1].

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (360.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4011 mL 12.0057 mL 24.0113 mL
5 mM 0.4802 mL 2.4011 mL 4.8023 mL
10 mM 0.2401 mL 1.2006 mL 2.4011 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

References
Molecular Weight

416.47

Formula

C₂₁H₂₁FN₂O₄S

CAS No.

844639-57-2

SMILES

O=C(O)CN1C2=C(C3=C1C=CC=C3)CC(N(S(=O)(C4=CC=C(F)C=C4)=O)C)CC2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
CAY10471 Racemate
目录号:
HY-13706
需求量:

CAY10471 Racemate

Cat. No.: HY-13706