2. GPCR/G Protein
  3. CRFR
  4. CP 316311

CP 316311 是一种有效的，选择性的 CRF1 receptor 拮抗剂，IC50 值为 6.8 nM。

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CP 316311 Chemical Structure

CP 316311 Chemical Structure

CAS No. : 175139-41-0

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CP 316311 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.

IC50 & Target

IC50: 6.8 nM (CRF1 receptor)[1]
体外研究
(In Vitro)

CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent Ki values of 7.6 and 8.5 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CP 316311 相关抗体:
体内研究
(In Vivo)

CP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic−pituitary−adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

327.46

Formula

C21H29NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP 316311 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP 316311175139-41-0CP316311CP-316311CRFRCorticotropin-releasing Factor ReceptorCRHRInhibitorinhibitorinhibit

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产品名称：
CP 316311
目录号：
HY-14129
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