2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Midaglizole hydrochloride

Midaglizole hydrochloride  (Synonyms: (±)-DG5128; DG5128)

目录号: HY-U00165 纯度: 99.67%
COA 产品使用指南

摩尔计算器

Midaglizole hydrochloride (DG5128) 是有效的 α2-肾上腺素受体拮抗剂。Midaglizole hydrochloride (DG5128) 对 α2-肾上腺素能受体的亲和力 (pKi= 6.28) 比 α1-肾上腺素能受体高 7.4 倍。

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Midaglizole hydrochloride Chemical Structure

Midaglizole hydrochloride Chemical Structure

CAS No. : 79689-25-1

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规格 价格 是否有货 数量
1 mg ￥1760
In-stock
5 mg ￥4400
In-stock
10 mg ￥7040
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Midaglizole hydrochloride:

Midaglizole hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Midaglizole hydrochloride (DG5128) is a preferential α2-adrenoceptor antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor.

IC50 & Target

α adrenergic receptor

 

体外研究
(In Vitro)

Midaglizole (DG-5128) at concentrations up to 10 μM inhibits [3H]clonidine binding more effectively than it doed [3H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition is homogeneous and consistent with the law of simple mass action[1]. The EC50 values for stimulation of insulin release from rat islets and the MIN6 β-cell line induced by Midaglizole are 200 nM and 24 μM, respectively. The IC50 values for KATP current inhibition induced by Midaglizole are 3.8 μM and 4.4 uM for Kir6.2 and Kir6.2/SUR1 , respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Midaglizole hydrochloride 相关抗体:
体内研究
(In Vivo)

Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

324.25

Formula

C16H19Cl2N3
CAS 号
性状

固体

颜色

White to off-white

中文名称

咪格列唑盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 500 mg/mL (1542.02 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0840 mL 15.4202 mL 30.8404 mL
5 mM 0.6168 mL 3.0840 mL 6.1681 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[3]

Rats[3]
Male Wistar rats (290-450 g) are anesthetized with pentobarbital sodium (35 mg/kg, i.p.) and artificially ventilated with room air. Diastolic blood pressure before the administration of the Midaglizole (Midaglizole) is about 35 mmHg. Midaglizole at doses of 3 and 30 mg/kg produces an increase in blood pressure by 27 and 64 mmHg, respectively, at approximately 1 min after the administration.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Midaglizole hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0840 mL 15.4202 mL 30.8404 mL 77.1010 mL
5 mM 0.6168 mL 3.0840 mL 6.1681 mL 15.4202 mL
10 mM 0.3084 mL 1.5420 mL 3.0840 mL 7.7101 mL
15 mM 0.2056 mL 1.0280 mL 2.0560 mL 5.1401 mL
20 mM 0.1542 mL 0.7710 mL 1.5420 mL 3.8551 mL
25 mM 0.1234 mL 0.6168 mL 1.2336 mL 3.0840 mL
30 mM 0.1028 mL 0.5140 mL 1.0280 mL 2.5700 mL
40 mM 0.0771 mL 0.3855 mL 0.7710 mL 1.9275 mL
50 mM 0.0617 mL 0.3084 mL 0.6168 mL 1.5420 mL
60 mM 0.0514 mL 0.2570 mL 0.5140 mL 1.2850 mL
80 mM 0.0386 mL 0.1928 mL 0.3855 mL 0.9638 mL
100 mM 0.0308 mL 0.1542 mL 0.3084 mL 0.7710 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Midaglizole79689-25-1(±)-DG5128 DG5128咪格列唑盐酸盐DG5128DG 5128DG-5128Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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