1. Neuronal Signaling
  2. Serotonin Transporter
    Dopamine Transporter

DOV-216,303 Free Base 

目录号: HY-18332C 纯度: 98.47%
产品使用指南

DOV-216,303 (Free Base) 是有效的 5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂,其对 hSERT、hNET 和 hDAT 的 IC50 值分别为 14 nM,20 nM和78 nM。在嗅球切除大鼠模型中,可增加前额皮质中单胺的释放及具有抗抑郁的作用。

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DOV-216,303 Free Base Chemical Structure

DOV-216,303 Free Base Chemical Structure

CAS No. : 66504-40-3

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3850 In-stock
5 mg ¥3500 In-stock
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Description

DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2].

IC50 & Target

IC50: 14 nM (serotonin), 20 nM (norepinephrine), 78 nM (dopamine)[1].

In Vivo

Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals[2].
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations[2].

Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2].
Dosage: 20 mg/kg.
Administration: I.P. daily for 17days.
Result: Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.
Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2].
Dosage: 20 mg/kg.
Administration: I.P. once.
Result: Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.
References
Molecular Weight

228.12

Formula

C₁₁H₁₁Cl₂N

CAS No.

66504-40-3

SMILES

ClC1=C(Cl)C=C(C=C1)C12CC1CNC2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
DOV-216,303 Free Base
目录号:
HY-18332C
需求量:

DOV-216,303 Free Base

Cat. No.: HY-18332C