1. Metabolic Enzyme/Protease
  2. Phosphatase

DT-061 

目录号: HY-112929
产品使用指南

DT-061 是一种具有口服生物活性的、蛋白磷酸酶 2A (PP2A) 的激活剂,可用于治疗 KRAS 突变和 MYC 驱动的肿瘤。

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DT-061 Chemical Structure

DT-061 Chemical Structure

CAS No. : 1809427-19-7

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  • 生物活性

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Description

DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1].

IC50 & Target

PP2A[1].

In Vivo

DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1].

Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1].
Dosage: 5 mg/kg.
Administration: Oral gavage for 4 weeks.
Result: Showed activity in inhibiting tumor growth.
References
Molecular Weight

520.52

Formula

C₂₅H₂₃F₃N₂O₅S

CAS No.

1809427-19-7

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@H]2[C@H](O)[C@@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
DT-061
目录号:
HY-112929
需求量:

DT-061

Cat. No.: HY-112929