2. Autophagy
  3. Autophagy
  4. Dansylcadaverine

Dansylcadaverine  (Synonyms: 丹酰尸胺; Monodansyl cadaverine)

目录号: HY-D1027 纯度: 98.62%
COA 产品使用指南

摩尔计算器

Dansylcadaverine (Monodansyl cadaverine) 是一种用于标记自噬空泡的自荧光化合物。Dansylcadaverine 是谷氨酰胺转胺酶的高亲和力底物，能阻断受体介导的多种配体的内吞作用。

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Dansylcadaverine Chemical Structure

Dansylcadaverine Chemical Structure

CAS No. : 10121-91-2

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规格 价格 是否有货 数量
50 mg ￥300
In-stock
100 mg ￥450
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Dansylcadaverine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2].

体外研究
(In Vitro)

The inhibitory activity of dansylcadaverine reflects its ability to serve as a substrate for transglutaminases and to block competitively the crosslinking of fibrin molecules[2].
? Dansylcadaverine, a cationic fluorescent probe binds to bacterial lipopolysaccharide and lipid A, and is displaced competitively by other compounds which possess affinity toward endotoxins[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dansylcadaverine 相关抗体:
分子量

335.46

Formula

C17H25N3O2S
CAS 号
性状

固体

颜色

White to off-white

中文名称

单丹磺酰戊二胺；丹酰尸胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 62.5 mg/mL (186.31 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9810 mL 14.9049 mL 29.8098 mL
5 mM 0.5962 mL 2.9810 mL 5.9620 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.62%

COA (192 KB) HNMR (229 KB) LCMS (265 KB)

产品使用指南 (1538 KB)
染色示例
参考文献
Kinase Assay
[1]

To determine the time course of transglutamination, thymosin β4 (120 μM) is incubated with Dansylcadaverine (5 mM) in 70 μL buffer consisting of 10 mM Tris-HCl, pH 7.4, 15 mM CaCl2, 3 mM DTT. The reaction is started by addition of 0.1 U transglutaminase. Immediately after addition of the enzyme (t=0) and at indicated times,10 μL are taken from the mixture, diluted in 490 μL 0.1% TFA to stop the reaction and analyzed by HPLC[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay

MCF7 cells (2.4×104) are seeded into 35 mm plates. After 24 h incubation, CuO NPs are added with an increasing concentration in the presence or absence of 3-Methyladenine (3-MA) for different time periods . The cells are then incubated with 50 mM Dansylcadaverine (MDC) at 37°C for 15 min and washed with 1×PBS three times with 5 min interval. Finally, the cells are observed under a fluorescence microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Dansylcadaverine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9810 mL 14.9049 mL 29.8098 mL 74.5245 mL
5 mM 0.5962 mL 2.9810 mL 5.9620 mL 14.9049 mL
10 mM 0.2981 mL 1.4905 mL 2.9810 mL 7.4525 mL
15 mM 0.1987 mL 0.9937 mL 1.9873 mL 4.9683 mL
20 mM 0.1490 mL 0.7452 mL 1.4905 mL 3.7262 mL
25 mM 0.1192 mL 0.5962 mL 1.1924 mL 2.9810 mL
30 mM 0.0994 mL 0.4968 mL 0.9937 mL 2.4842 mL
40 mM 0.0745 mL 0.3726 mL 0.7452 mL 1.8631 mL
50 mM 0.0596 mL 0.2981 mL 0.5962 mL 1.4905 mL
60 mM 0.0497 mL 0.2484 mL 0.4968 mL 1.2421 mL
80 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.9316 mL
100 mM 0.0298 mL 0.1490 mL 0.2981 mL 0.7452 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dansylcadaverine10121-91-2Monodansyl cadaverine单丹磺酰戊二胺丹酰尸胺AutophagyautofluorescentprobeautophagicvacuolessubstrateInhibitorinhibitorinhibit

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