2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Datelliptium chloride

Datelliptium chloride 

目录号: HY-U00337 纯度: 99.63%
COA 产品使用指南

摩尔计算器

Datelliptium chloride 是一种源于 ellipticine 的 DNA 嵌合剂，具有抗肿瘤活性。

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Datelliptium chloride Chemical Structure

Datelliptium chloride Chemical Structure

CAS No. : 105118-14-7

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规格 价格 是否有货 数量
1 mg ￥6800
In-stock
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Other Forms of Datelliptium chloride:

Datelliptium chloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities.

体外研究
(In Vitro)

Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells[1]. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Datelliptium chloride 相关抗体:
体内研究
(In Vivo)

Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

397.94

Formula

C23H28ClN3O
CAS 号
性状

固体

颜色

Pink to red

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 41.67 mg/mL (104.71 mM; 超声助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5129 mL 12.5647 mL 25.1294 mL
5 mM 0.5026 mL 2.5129 mL 5.0259 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.63%

COA (264 KB) HNMR (227 KB) LCMS (119 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

Cytotoxicity is estimated after short-term exposure (2 hr) to datelliptium using suspended and cultured rat hepatocytes. When cytotoxicity is evaluated after longer-term exposure, using human and rat monolayers and hepatoma cell lines, the compound is added 1 hr after cell plating and incubated for 23 hr. The loss of intracellular LDH and the MTT test are the endpoints evaluated in cultured cells. The intracellular LDH is measured in the microwell culture plates by a colorimetric method. The MTT test, reduction of the tetrazolium salt MTT to formazan by mitochondrial succinate dehydrogenase, is performed as described. Cytotoxicity in the hepatocyte suspension is evaluated by LDH leakage to the medium after a 2-hr treatment with the drug.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Datelliptium chloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5129 mL 12.5647 mL 25.1294 mL 62.8235 mL
5 mM 0.5026 mL 2.5129 mL 5.0259 mL 12.5647 mL
10 mM 0.2513 mL 1.2565 mL 2.5129 mL 6.2824 mL
15 mM 0.1675 mL 0.8376 mL 1.6753 mL 4.1882 mL
20 mM 0.1256 mL 0.6282 mL 1.2565 mL 3.1412 mL
25 mM 0.1005 mL 0.5026 mL 1.0052 mL 2.5129 mL
30 mM 0.0838 mL 0.4188 mL 0.8376 mL 2.0941 mL
40 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5706 mL
50 mM 0.0503 mL 0.2513 mL 0.5026 mL 1.2565 mL
60 mM 0.0419 mL 0.2094 mL 0.4188 mL 1.0471 mL
80 mM 0.0314 mL 0.1571 mL 0.3141 mL 0.7853 mL
100 mM 0.0251 mL 0.1256 mL 0.2513 mL 0.6282 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Datelliptium105118-14-7DNA/RNA SynthesisInhibitorinhibitorinhibit

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