1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

EGFR-IN-5 

目录号: HY-111415
产品使用指南

EGFR-IN-5是 EGFR 的抑制剂,对EGFR,EGFRL858R,EGFRL858R/T790M和EGFRL858R/T790M/C797SIC50分别为10.4,1.1,34,7.2 nM。

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EGFR-IN-5 Chemical Structure

EGFR-IN-5 Chemical Structure

CAS No. : 2225887-26-1

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Description

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

IC50 & Target[1]

EGFR

10.4 nM (IC50)

EGFRL858R

1.1 nM (IC50)

EGFRL858R/T790M

34 nM (IC50)

EGFRL858R/T790M/C797S

7.2 nM (IC50)

References
Molecular Weight

571.69

Formula

C₃₁H₃₈FN₉O

CAS No.

2225887-26-1

SMILES

OCC(CC1)CCN1C2=NC(NC3=CC=C(F)C=C3)=NC(C=N4)=C2C=C4NC5=NC=C(N6CCC(N(C)C)CC6)C=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
EGFR-IN-5
目录号:
HY-111415
需求量:

EGFR-IN-5

Cat. No.: HY-111415