1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

ERK1/2 inhibitor 1 

目录号: HY-112287
产品使用指南

ERK1/2 inhibitor 1 是一种有效的,口服生物可利用的 ERK1/2 抑制剂,在 1 nM 时抑制 ERK1 达60%,抑制 ERK2 的 IC50 为 3.0 nM。

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ERK1/2 inhibitor 1 Chemical Structure

ERK1/2 inhibitor 1 Chemical Structure

CAS No. : 2095719-90-5

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Description

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].

IC50 & Target[1]

ERK2

3.0 nM (IC50)

ERK1

 

In Vitro

ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].

References
Molecular Weight

550.05

Formula

C₂₉H₃₂ClN₅O₄

CAS No.

2095719-90-5

SMILES

ClC1=CN=C(NC2CCOCC2)N=C1C3=CC=C(CN([C@H](C)C(N[C@H](CO)C4=CC=CC(C)=C4)=O)C5=O)C5=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
ERK1/2 inhibitor 1
目录号:
HY-112287
需求量:

ERK1/2 inhibitor 1

Cat. No.: HY-112287