1. GPCR/G Protein Neuronal Signaling
  2. Opioid Receptor
  3. Endomorphin 1

Endomorphin 1  (Synonyms: 内吗啡肽 1)

目录号: HY-P0185 纯度: 99.92%
COA 产品使用指南

Endomorphin 1,一种高度选择性的,高亲和力的 μ-opioid 受体激动剂 (Ki: 1.11 nM),对 kappa3结合位点具有高亲和力,Ki 值为 20 到 30 nM 之间。Endomorphin 1 具有镇痛特性。

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Custom Peptide Synthesis

Endomorphin 1 Chemical Structure

Endomorphin 1 Chemical Structure

CAS No. : 189388-22-5

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10 mM * 1 mL in Water ¥672
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5 mg ¥500
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10 mg ¥700
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25 mg ¥1400
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Other Forms of Endomorphin 1:

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties[1][2][4].

IC50 & Target

μ Opioid Receptor/MOR

1.11 nM (Ki)

体外研究
(In Vitro)

Endomorphin 1 inhibits Forskolin (HY-15371) (1 μM) stimulated cyclic AMP formation with a pIC50 value of 8.03 in In CHOμ cells[5].
Endomorphin 1 (1-10 μM) increases interleukin-8 secretion in Caco-2 cells[6].
Endomorphin 1 (1 μM) inhibits excitatory transmission in adult rat substantia gelatinosa neurons[7].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Endomorphin 1 (i.c.v.) shows antinociceptive properties in mice, with an ED50 value of 6.16 nM[2].
Endomorphin 1 (50 μg/kg, i.v.) alleviates myocardial ischemia/reperfusion injury (MIRI) by inhibiting the inflammatory response[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[2].
Dosage: 6.16 nM (ED50)
Administration: Intracerebroventricularly (i.c.v.) injection
Result: Inhibited dose-dependently the tail-flick response.
Animal Model: Rats[3].
Dosage: 50 μg/kg
Administration: Intravenously following LAD ligation for 25 min, subsequently the LAD was reperfused for 120 min.
Result: Alleviated MIRI by reducing the production of free radicals.
Dncreased LDH and CK-MB activities.
Increased SOD activity and decreased MDA content.
Decreased IL-6 and TNF-α plasma content.
分子量

610.70

Formula

C34H38N6O5

CAS 号
性状

固体

颜色

White to off-white

Sequence

Tyr-Pro-Trp-Phe-NH2

Sequence Shortening

YPWF-NH2

中文名称

内吗啡肽 1

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 50 mg/mL (81.87 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6375 mL 8.1873 mL 16.3747 mL
5 mM 0.3275 mL 1.6375 mL 3.2749 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6375 mL 8.1873 mL 16.3747 mL 40.9366 mL
5 mM 0.3275 mL 1.6375 mL 3.2749 mL 8.1873 mL
10 mM 0.1637 mL 0.8187 mL 1.6375 mL 4.0937 mL
15 mM 0.1092 mL 0.5458 mL 1.0916 mL 2.7291 mL
20 mM 0.0819 mL 0.4094 mL 0.8187 mL 2.0468 mL
25 mM 0.0655 mL 0.3275 mL 0.6550 mL 1.6375 mL
30 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3646 mL
40 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0234 mL
50 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.8187 mL
60 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.6823 mL
80 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Endomorphin 1
目录号:
HY-P0185
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