1. Metabolic Enzyme/Protease
  2. Dopamine β-hydroxylase

Etamicastat (Synonyms: BIA 5-453)

目录号: HY-14838
产品使用指南

Etamicastat (BIA 5-453) 是一种有效的,可逆的外周多巴胺-β-羟化酶 (DβH) 抑制剂。

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Etamicastat Chemical Structure

Etamicastat Chemical Structure

CAS No. : 760173-05-5

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Description

Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor[1].

IC50 & Target

Dopamine-β-hydroxylase (DβH)[1]

In Vivo

Upon intraperitoneal administration to NMRi mice, Etamicastat (100 mg/ kg) leads to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control)[2].
Etamicastat (50 mg/kg) is rapidly absorbed into the systemic circulation reaching a maximum concentration at 4 h post-administration, representing 29% of total Etamicastat and quantified metabolites, using AUC0-t as a measure of systemic exposure[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2118 mL 16.0591 mL 32.1182 mL
5 mM 0.6424 mL 3.2118 mL 6.4236 mL
10 mM 0.3212 mL 1.6059 mL 3.2118 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

311.35

Formula

C₁₄H₁₅F₂N₃OS

CAS No.

760173-05-5

SMILES

S=C1NC=C(CCN)N1[C@H]2COC3=C(C=C(F)C=C3F)C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
Etamicastat
目录号:
HY-14838
需求量:

Etamicastat

Cat. No.: HY-14838