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GB1107 

目录号: HY-114409
产品使用指南

GB1107 是一个有效的、选择性的、具有口服活性的 半乳糖凝集素 3 (Gal-3) 的抑制剂,其对人Gal-3的Kd 值为 37 nM。GB1107 可降低人和小鼠肺腺癌的生长并抑制转移。

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GB1107 Chemical Structure

GB1107 Chemical Structure

CAS No. : 1978336-61-6

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Description

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1].

IC50 & Target

Kd: 37 nM (human Gal-3)[1].

In Vitro

Treatment with GB1107 (0-1 μM) increases tumor M1 macrophage polarization and CD8+ T cell infiltration in LLC cells by flow cytometric analysis. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules[1].

In Vivo

GB1107 (10 mg/kg, p.o., once daily from day 18-30 post implantation) treatment results in significantly reduced tumor growth and final tumor weights[1].

Animal Model: CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549)[1].
Dosage: 10 mg/kg
Administration: Oral once daily from day 18-30 post implantation.
Result: Resulted in significantly reduced tumor growth and final tumor weights.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

522.32

Formula

C₂₀H₁₆Cl₂F₃N₃O₄S

CAS No.

1978336-61-6

SMILES

O[C@H]([C@@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@H]3SC4=CC=C(Cl)C(Cl)=C4

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
GB1107
目录号:
HY-114409
需求量:

GB1107

Cat. No.: HY-114409