1. Membrane Transporter/Ion Channel
  2. EAAT2

GT 949 

目录号: HY-114381
产品使用指南

GT 949 是一种选择性的兴奋性氨基酸转运蛋白-2 (EAAT2) 阳性变构调节剂,EC50 为 0.26 nM。

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GT 949 Chemical Structure

GT 949 Chemical Structure

CAS No. : 460330-27-2

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Description

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM[1].

IC50 & Target

EC50: 0.26±0.03 nM (EAAT2)[1]

In Vitro

GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3[1].
GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%[1].

References
Molecular Weight

527.66

Formula

C₃₀H₃₇N₇O₂

CAS No.

460330-27-2

SMILES

O=C1NC2=C(C=C(OC)C=C2)C=C1C(N3CCN(C4CCCCC4)CC3)C5=NN=NN5CCC6=CC=CC=C6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
GT 949
目录号:
HY-114381
需求量:

GT 949

Cat. No.: HY-114381