2. Membrane Transporter/Ion Channel
  3. EAAT
  4. GT 949

GT 949 是一种选择性的兴奋性氨基酸转运蛋白-2 (EAAT2) 阳性变构调节剂，EC50 为 0.26 nM。

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GT 949 Chemical Structure

GT 949 Chemical Structure

CAS No. : 460330-27-2

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GT 949 相关抗体

Top Publications Citing Use of Products

查看 EAAT 亚型特异性产品:

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EAAT1 EAAT2 EAAT3 EAAT4 EAAT5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM[1].

IC50 & Target

EAAT2

 

体外研究
(In Vitro)

GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3[1].
GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GT 949 相关抗体:
分子量

527.66

Formula

C30H37N7O2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

GT 949 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GT 949460330-27-2GT949GT-949EAATExcitatory amino acid transporter Glutamate transporter;Inhibitorinhibitorinhibit

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产品名称：
GT 949
目录号：
HY-114381
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