2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Gidazepam

Gidazepam  (Synonyms: Gidasepam; Hidazepam; Hydazepam)

目录号: HY-U00315 纯度: 98.03%
COA 产品使用指南

摩尔计算器

Gidazepam 是一种 GABA 受体通道 (GABA RCs) 激动剂。

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Gidazepam Chemical Structure

Gidazepam Chemical Structure

CAS No. : 129186-29-4

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规格 价格 是否有货 数量
1 mg ￥500
In-stock
5 mg ￥900
In-stock
10 mg ￥1500
In-stock
25 mg ￥3000
In-stock
50 mg ￥4800
In-stock
100 mg ￥7800
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Gidazepam:

Gidazepam 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gidazepam is an agonist of GABA receptor channels (GABA RCs).

IC50 & Target

GABA receptor[1]
体外研究
(In Vitro)

Gidazepam demonstrates considerably lower affinities to GABA RCs than phenazepam, 3-hydrozyphenazepam, and Br-nordiazepam. This is manifested in different values of the inhibition constant (Ki) of binding of a specific ligand of benzodiazepine receptors, diazepam. For Gidazepam, the Ki value is 2,200±50 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gidazepam 相关抗体:
体内研究
(In Vivo)

Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam (GDZ, 1 mg/kg); ester 1 (175 mg/kg); ester 2 (20 mg/kg); esters 3 and 4 (200 mg/kg); mixtures of Gidazepam and esters 1-4. All esters of GABA with monoterpenes display antiseizure effects in 3 h after oral administration as evidenced by increasing of inducing clonic-tonic convulsions (DCTC) and tonic extension (DTE) values. Gidazepam (1 mg/kg) is found to protect against seizures with DCTC and DTE values of 250% and 215%, accordingly; whereas co-administration of Gidazepam and esters 5-7 is shown to increase anticonvulsant activity compared with each compound alone[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

387.23

Formula

C17H15BrN4O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

吉达西泮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (645.61 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5824 mL 12.9122 mL 25.8244 mL
5 mM 0.5165 mL 2.5824 mL 5.1649 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
The outbreed male white mice (18-22 g) are used. Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam 1 mg/kg (GDZ); GABA ester of menthol 175 mg/kg (1); GABA ester of thymol 20 mg/kg (2); GABA ester of carvacrol 200 mg/kg (3); GABA ester of guaiacol 200 mg/kg (4); mixture of Gidazepam and 1; mixture of Gidazepam and 2; mixture of Gidazepam and 3; mixture of Gidazepam and 4. Doses of esters 1-4 are calculated in equimolar amounts with respect to monoterpenes based on our preliminary investigation and from literature citations. The anticonvulsant activity of compounds 1-4 and Gidazepam as well as mixtures of Gidazepam with 1-4 is evaluated in model of acute generalized seizures; pharmacological effect of compounds is estimated in 3 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Gidazepam 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5824 mL 12.9122 mL 25.8244 mL 64.5611 mL
5 mM 0.5165 mL 2.5824 mL 5.1649 mL 12.9122 mL
10 mM 0.2582 mL 1.2912 mL 2.5824 mL 6.4561 mL
15 mM 0.1722 mL 0.8608 mL 1.7216 mL 4.3041 mL
20 mM 0.1291 mL 0.6456 mL 1.2912 mL 3.2281 mL
25 mM 0.1033 mL 0.5165 mL 1.0330 mL 2.5824 mL
30 mM 0.0861 mL 0.4304 mL 0.8608 mL 2.1520 mL
40 mM 0.0646 mL 0.3228 mL 0.6456 mL 1.6140 mL
50 mM 0.0516 mL 0.2582 mL 0.5165 mL 1.2912 mL
60 mM 0.0430 mL 0.2152 mL 0.4304 mL 1.0760 mL
80 mM 0.0323 mL 0.1614 mL 0.3228 mL 0.8070 mL
100 mM 0.0258 mL 0.1291 mL 0.2582 mL 0.6456 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gidazepam129186-29-4Gidasepam Hidazepam Hydazepam吉达西泮GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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