1. Metabolic Enzyme/Protease
  2. FXR

Gly-​β-MCA 

目录号: HY-114392
产品使用指南

Gly-β-MCA 是一种胆汁酸,是有效的、稳定的、肠特异性的以及具有口服生物活性的法尼酯X受体 (FXR) 抑制剂,可能会成为治疗代谢障碍的候选药物。

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Gly-​β-MCA Chemical Structure

Gly-​β-MCA Chemical Structure

CAS No. : 66225-78-3

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Size Price Stock
5 mg ¥2200 Get quote
10 mg ¥3500 Get quote

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  • 生物活性

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Description

Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders[1].

IC50 & Target

FXR[1].

In Vitro

Gly-β-MCA, a bile acid, is a potent, sable and intestine-selective and farnesoid X receptor (FXR) inhibitor[1].
Gly-β-MCA (Gly-MCA, ) is resistant to hydrolysis by BSH[1].

In Vivo

Gly-β-MCA (Gly-MCA, p.o. 10 and 50 mg/kg) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice[1].
Gly-MCA does not increase faecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1477 mL 10.7384 mL 21.4767 mL
5 mM 0.4295 mL 2.1477 mL 4.2953 mL
10 mM 0.2148 mL 1.0738 mL 2.1477 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

465.62

Formula

C₂₆H₄₃NO₆

CAS No.

66225-78-3

SMILES

C[C@@H]([C@@]1([H])CC[C@@]2([H])[C@@]3([H])[C@]([C@]4(CC[C@@H](O)C[C@H]4[C@H](O)[C@@H]3O)C)([H])CC[C@]12C)CCC(NCC(O)=O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Gly-​β-MCA
目录号:
HY-114392
需求量:

Gly-​β-MCA

Cat. No.: HY-114392