1. GPCR/G Protein
  2. Adrenergic Receptor

Guanfacine hydrochloride (Synonyms: Guanfacine)

目录号: HY-17416 纯度: 99.96%
产品使用指南

Guanfacine盐酸盐是α2A肾上腺素受体激动剂,Kd为31 nM,具有抗高血压的活性。

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Guanfacine hydrochloride Chemical Structure

Guanfacine hydrochloride Chemical Structure

CAS No. : 29110-48-3

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥563 In-stock
10 mg ¥512 In-stock
50 mg ¥1600 In-stock
100 mg ¥2300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Guanfacine hydrochloride:

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Description

Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors. IC50 Value: 31 nM(Kd) Target: Adrenergic Receptor Guanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. From Wikipedia

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (106.18 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5392 mL 17.6960 mL 35.3920 mL
5 mM 0.7078 mL 3.5392 mL 7.0784 mL
10 mM 0.3539 mL 1.7696 mL 3.5392 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

References
Molecular Weight

282.55

Formula

C₉H₁₀Cl₃N₃O

CAS No.

29110-48-3

SMILES

O=C(NC(N)=N)CC1=C(Cl)C=CC=C1Cl.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.96%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Guanfacine hydrochloride
目录号:
HY-17416
需求量:

Guanfacine hydrochloride

Cat. No.: HY-17416