1. Metabolic Enzyme/Protease
  2. HMG-CoA Reductase (HMGCR)
  3. HMG499

HMG499 

目录号: HY-114316
产品使用指南

HMG499是有效,选择性的 HMG-CoA还原酶 抑制剂, EC50为 0.41 μM。HMG499可预防他汀类药物诱导的HMGCR积聚,降低血清胆固醇水平,减少动脉粥样硬化。

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HMG499 Chemical Structure

HMG499 Chemical Structure

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Description

HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis[1].

IC50 & Target

IC50: 0.41 μM (HMG-CoA reductase)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

498.78

Formula

C₃₃H₅₄O₃

SMILES

O[C@H](C1(C)C)CC[C@@]2(C)C1=C[C@H](O)C3C2CC[C@@]4(C)C3CC[C@@H]4[C@@H](CCCC(CC=C)(O)CC=C)C

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
HMG499
目录号:
HY-114316
需求量:

HMG499

Cat. No.: HY-114316